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Molecular Approach for the Study of Penicillin Resistance In Neisseria meningitidis

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Meningococcal Disease

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 67))

Abstract

Neisseria meningitidis was previously considered extremely susceptible to penicillin, with most isolates showing minimal inhibitory concentrations (MICs) of ≦ 0.06 μg/mL. However, meningococcal isolates with decreased susceptibility to penicillin have been reported from asymptomatic carriers from as long ago as 1964 (1). Since then, meningococcal clinical isolates with decreased susceptibility to penicillin have been widely described in different countries, with MICs between 0.12 μg/mL to 1 μg/mL (2–9).

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Author information

Authors and Affiliations

  1. Reference Laboratory for Meningococci, National Center for Microbiology, Madrid, Spain

    Luisa Arreaza & Julio A. Vázquez

Authors
  1. Luisa Arreaza
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  2. Julio A. Vázquez
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Editor information

Editors and Affiliations

  1. BC Research Institute for Children’s and Women’s Health, Vancouver, BC, Canada

    Andrew J. Pollard MD, PhD

  2. Wellcome Trust Centre for the Epidemiology of Infectious Disease, Oxford, UK

    Martin C. J. Maiden PhD

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© 2001 Humana Press Inc., Totowa, NJ

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Arreaza, L., Vázquez, J.A. (2001). Molecular Approach for the Study of Penicillin Resistance In Neisseria meningitidis . In: Walker, J.M., Pollard, A.J., Maiden, M.C.J. (eds) Meningococcal Disease. Methods in Molecular Medicine™, vol 67. Humana Press. https://doi.org/10.1385/1-59259-149-3:107

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  • DOI: https://doi.org/10.1385/1-59259-149-3:107

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-849-3

  • Online ISBN: 978-1-59259-149-7

  • eBook Packages: Springer Protocols

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