Molecular Analysis of Gene-Polymorphisms Affecting the Host Response to Infection

  • Rudi G. J Westendorp
  • Tom W. J Huizinga
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 67)


The genetic regulation of the host response to infection is crucial for understanding susceptibility to and outcome of meningococcal disease. The initial host response depends on the innate immune system, after which specific immunity is attained when antibodies from the adaptive immune system appear. The comparison of genetic markers in patients who have suffered from the disease, their families, and appropriate control populations thus identifies components of the host response that are key to combat meningococcal infection. A similar reasoning can be followed when studying susceptibility to or when studying outcome of meningococcal disease. A better understanding of the host response at a molecular level also allows for estimating individual risk. This accumulating knowledge can be used to develop new preventive and therapeutic interventions and to vary these strategies dependent on risk profiles.


Adverse Outcome Host Response Control Person Functional Polymorphism Meningococcal Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 2001

Authors and Affiliations

  • Rudi G. J Westendorp
    • 1
  • Tom W. J Huizinga
    • 2
  1. 1.Department of General Internal Medicine and Clinical EpidemiologyLeiden University Medical CenterLeidenThe Netherlands
  2. 2.Department of RheumatologyLeiden University Medical CenterLeidenThe Netherlands

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