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Meningococcal Disease pp 121–130Cite as

Overview: Epidemiology, Surveillance, and Population Biology

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Part of the Methods in Molecular Medicine™ book series (MIMM,volume 67)

Abstract

A combination of data obtained by classical epidemiological techniques with insights gained from the analysis of the population biology of Neisseria meningitidis have proved to be critical in understanding the spread of menin-gococcal disease. This is a consequence of the natural history and evolution of this bacterium, which, despite its fearsome reputation as an aggressive pathogen (1), is ordinarily a harmless commensal inhabitant of the nasopharynx of adult humans (2). Further, it has been established that “natural,” (that is to say, carried) populations of meningococci are highly diverse, with a minority of genotypes (the “hyperinvasive lineages”) being responsible for the majority of disease (3). Finally, it is known that distinct hyperinvasive lineages tend to be associated with particular epidemiological manifestations of meningococcal disease (4) and some are especially associated with severe disease (the “hyper-virulent” lineages) (5). These complexities have important implications for public-health interventions, as different disease epidemiologies, caused by genetically diverse meningococci, require distinct approaches to public-health management. For example, the public-health response necessary to combat large-scale meningococcal-disease outbreaks in Africa (6) is different from that required during an institutional disease outbreak in Europe and North America, and prolonged geographical outbreaks in these countries require a different response again (7). In recognition of the importance of the multi-disciplinary approach necessary to establish these insights, this section contains chapters ranging from outbreak management through surveillance and isolate characterization techniques to phylogenetic methods. Together the chapters provide the methodologies necessary for monitoring, understanding, and reacting to the spread of meningococcal disease.

Keywords

  • Meningococcal Disease
  • Neisseria Meningitidis
  • Clonal Complex
  • Polysaccharide Vaccine
  • Complement Deficiency

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Peltola H. (1983) Meningococcal disease: still with us. Rev. Infect. Dis. 5, 71–91.

    CAS  PubMed  Google Scholar 

  2. Broome C. V. (1986) The carrier state: Neisseria meningitidis. J. Antimicrob. Chemother. 18(Suppl. A), 25–34.

    Google Scholar 

  3. Caugant D. A., Froholm L. O., Sacchi C. T., and Selander R. K. (1991) Genetic structure and epidemiology of serogroup B Neisseria meningitidis, in Neisseriae 1990 (Achtman M., Kohl P., Marchal C., Morelli G., Seiler A., and Thiesen B., eds.), Walter de Gruyter, Berlin, pp. 37–42.

    Google Scholar 

  4. Maiden M. C. J. and Feavers I. M. (1995) Population genetics and global epidemiology of the human pathogen Neisseria meningitidis, in Population Genetics of Bacteria (Baumberg S., Young J. P. W., Wellington E. M. H., and Saunders J. R., eds.), Cambridge University Press, Cambridge, UK, pp. 269–293.

    Google Scholar 

  5. Whalen C. M., Hockin J. C., Ryan A., and Ashton F. (1995) The changing epidemiology of invasive meningococcal disease in Canada, 1985 through 1992. Emergence of a virulent clone of Neisseria meningitidis. JAMA 273, 390–394.

    CAS  CrossRef  PubMed  Google Scholar 

  6. Hart C. A., Cuevas L. E., Marzouk O., Thomson A. P., and Sills J. (1993) Management of bacterial meningitis. J. Antimicrob. Chemother. 32(Suppl. A), 49–59.

    PubMed  Google Scholar 

  7. Begg N. (1995) Outbreak management, in Meningococcal Disease (Cartwright K. A. V., ed.), John Wiley and Sons, Sons, Chichester, UKhichester, UK, pp. 286–305.

    Google Scholar 

  8. Cartwright K. A. V. (1995) Meningococcal Disease. John Wiley & Sons, Sons, Chichester, UKhichester, UK.

    Google Scholar 

  9. Branham S. E. (1953) Serological relationships among meningococci. Bact. Rev. 17, 175–188.

    CAS  PubMed  Google Scholar 

  10. Vedros N. A. (1987) Development of meningococcal serogroups, in Evolution of Meningococcal Disease; vol. II (Vedros N. A., ed.), CRC Press Inc., Boca Raton, FL, pp. 33–37.

    Google Scholar 

  11. Frasch C. E., Zollinger W. D., and Poolman J. T. (1985) Serotype antigens of Neisseria meningitidis and a proposed scheme for designation of serotypes. Rev. Infect. Dis. 7, 504–510.

    CAS  PubMed  Google Scholar 

  12. Moore P. S. and Broome C. V. (1994) Cerebrospinal meningitis epidemics. Sci. Am. 271, 24–31.

    CrossRef  Google Scholar 

  13. Lapeyssonnie L. (1963) La meningite cerebrospinale en Afrique. Bull. WHO 28(Suppl.), 53–114.

    Google Scholar 

  14. Schwartz B., Moore P. S., and Broome C. V. (1989) Global epidemiology of meningococcal disease. Clin. Microbiol. Rev. 2, 118–124.

    Google Scholar 

  15. Achtman M. (1991) Clonal properties of meningococci from epidemic meningitis. Trans. R. Soc. Trop. Med. Hyg. 85(Suppl. 1), 24–31.

    CrossRef  PubMed  Google Scholar 

  16. Achtman M. (1990) Molecular epidemiology of epidemic bacterial meningitis. Rev. Med. Microbiol. 1, 29–38.

    Google Scholar 

  17. Wang J.-F., Caugant D. A., Li X., Hu X., Poolman J. T., Crowe B. A., and Achtman M. (1992) Clonal and antigenic analysis of serogroup A Neisseria meningitidis with particular reference to epidemiological features of epidemic meningitis in China. Infect. Immun. 60, 5267–5282.

    CAS  PubMed  Google Scholar 

  18. Mohammed I., Nasidi A., Alkali A. S., Garbati M. A., Ajayi-Obe E. K., Audu K. A., et al. (2000) A severe epidemic of meningococcal meningitis in Nigeria, 1996. Trans. R. Soc. Trop. Med. Hyg. 94, 265–270.

    CAS  CrossRef  PubMed  Google Scholar 

  19. Moore P. S., Harrison L. H., Telzak E. E., Ajello G. W., and Broome C. V. (1988) Group A meningococcl carriage in travelers returning from Saudi Arabia. JAMA 260, 2686–2689.

    CAS  CrossRef  PubMed  Google Scholar 

  20. Popovic T., Sacchi C. T., Reeves M. W., Whitney A. M., Mayer L. W., Noble C. A., et al. (2000) Neisseria meningitidis serogroup W135 isolates associated with the ET-37 complex [letter]. Emerg. Infect. Dis. 6, 428–429.

    CAS  CrossRef  PubMed  Google Scholar 

  21. Hansman D. (1983) Meningococcal disease in South Australia: incidence and serogroup distribution 1971-1980. J. Hyg. 90, 49–54.

    CAS  CrossRef  Google Scholar 

  22. Kaczmarski E. B. (1997) Meningococcal infections in England and Wales. Com-muni. Dis. Rep. Rev. 7, R55–R59.

    CAS  Google Scholar 

  23. Barquet N., Domingo P., Cayla J. A., Gonzalez J., Rodrigo C., Fernandez-Viladrich P., et al. (1999) Meningococcal disease in a large urban population (Barcelona, 1987-1992): predictors of dismal prognosis. Barcelona Meningococcal Disease Surveillance Group. Arch. Intern. Med. 159, 2329–2340.

    CAS  CrossRef  PubMed  Google Scholar 

  24. Krizova P., Musilek M., and Kalmusova J. (1997) Development of the epide-miological situation in invasive meningococcal disease in the Czech Republic caused by emerging Neisseria meningitidis clone ET-15/37. Cent. Eur. J. Public Health 5, 214–218.

    CAS  PubMed  Google Scholar 

  25. Kremastinou J., Tzanakaki G., Velonakis E., Voyiatzi A., Nickolaou A., Elton R. A., et al. (1999) Carriage of Neisseria meningitidis and Neisseria lactamica among ethnic Greek school children from Russian immigrant families in Athens. FEMS Immunol. Med. Microbiol. 23, 13–20.

    CAS  PubMed  Google Scholar 

  26. Caugant D. A., Mocca L. F., Frasch C. E., Froholm L. O., Zollinger W. D., and Selander R. K. (1987) Genetic structure of Neisseria meningitidis populations in relation to serogroup, serotype, and outer membrane protein pattern. J. Bacteriol. 169, 2781–2792.

    CAS  PubMed  Google Scholar 

  27. Caugant D. A., Froholm L. O., Bovre K., Holten E., Frasch C. E., Mocca L. F., et al. (1987) Intercontinental spread of Neisseria meningitidis clones of the ET-5 complex. Antonie van Leeuwenhoek J. Microbiol. 53, 389–394.

    CAS  CrossRef  PubMed  Google Scholar 

  28. Maiden M. C. J., Bygraves J. A., Feil E., Morelli G., Russell J. E., Urwin R., et al. (1998) Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc. Natl. Acad. Sci. USA 95, 3140–3145.

    CAS  CrossRef  PubMed  Google Scholar 

  29. Caugant D. A., Kristiansen B. E., Froholm L. O., Bovre K., and Selander R. K. (1988) Clonal diversity of Neisseria meningitidis from a population of asymptomatic carriers. Infect. Immun. 56, 2060–2068.

    CAS  PubMed  Google Scholar 

  30. Maiden M. C. J. (1993) Population genetics of a transformable bacterium: the influence of horizontal genetical exchange on the biology of Neisseria meningitidis. FEMS Microbiol. Lett. 112, 243–250.

    CAS  CrossRef  PubMed  Google Scholar 

  31. Gupta S., Maiden M. C. J., Feavers I. M., Nee S., May R. M., and Anderson R. M. (1996) The maintenance of strain structure in populations of recombining infectious agents. Nat. Med. 2, 437–442.

    CAS  CrossRef  PubMed  Google Scholar 

  32. Bygraves J. A. and Maiden M. C. J. (1992) Analysis of the clonal relationships between strains of Neisseria meningitidis by pulsed field gel electrophoresis. J. Gen. Microbiol. 138, 523–531.

    CAS  PubMed  Google Scholar 

  33. Parkhill J., Achtman M., James K. D., Bentley S. D., Churcher C., Klee S. R., et al. (2000) Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature 404, 502–506.

    CAS  CrossRef  PubMed  Google Scholar 

  34. Tettelin H., Saunders N. J., Heidelberg J., Jeffries A. C., Nelson K. E., Eisen J. A., et al. (2000) Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science 287, 1809–1815.

    CAS  CrossRef  PubMed  Google Scholar 

  35. Carrol E. D., Thomson A. P., Shears P., Gray S. J., Kaczmarski E. B., and Hart C. A. (2000) Performance characteristics of the polymerase chain reaction assay to confirm clinical meningococcal disease. Arch. Dis. Child 83, 271–273.

    CAS  CrossRef  PubMed  Google Scholar 

  36. Pollard A. J. and Levin M. (2000) Vaccines for prevention of meningococcal disease. Pediatr. Infect. Dis. J. 19, 333–444.

    CAS  CrossRef  PubMed  Google Scholar 

  37. Gotschlich E. C., Goldschneider I., and Artenstein M.S. (1969) Human immunity to the meningococcus IV. Immunogenicity of group A and group C meningococcal polysaccharides. J. Exp. Med. 129, 1367–1384.

    CAS  CrossRef  PubMed  Google Scholar 

  38. Finne J., Leinonen M., and Makela P.H. (1983) Antigenic similarities between brain components and bacteria causing meningitis: implications for vaccine development and pathogenesis. Lancet ii, 355–357.

    CrossRef  Google Scholar 

  39. Bjune G., Closs O., Froholm L. O., Gronnesby J. K., Hoiby E. A., and Nokleby H. (1991) Design of clinical trials with an outer membrane vesicle vaccine against systemic serogroup B meningococcal disease in Norway. NIPH. Ann. 14, 81–91.

    CAS  PubMed  Google Scholar 

  40. de Moraes J. C., Perkins B. A., Camargo M. C., Hidalgo N. T., Barbosa H. A., Sacchi C. T., et al. (1992) Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil. Lancet 340, 1074–1078.

    CrossRef  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Zoology, University of Oxford, Oxford, UK

    Martin C. J. Maiden

  2. SmithKline Beecham, Hertsfordshire, UK

    Norman T. Begg

Authors
  1. Martin C. J. Maiden
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  2. Norman T. Begg
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Editor information

Editors and Affiliations

  1. BC Research Institute for Children’s and Women’s Health, Vancouver, BC, Canada

    Andrew J. Pollard MD, PhD

  2. Wellcome Trust Centre for the Epidemiology of Infectious Disease, Oxford, UK

    Martin C. J. Maiden PhD

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© 2001 Humana Press Inc., Totowa, NJ

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Maiden, M.C.J., Begg, N.T. (2001). Overview: Epidemiology, Surveillance, and Population Biology. In: Walker, J.M., Pollard, A.J., Maiden, M.C.J. (eds) Meningococcal Disease. Methods in Molecular Medicine™, vol 67. Humana Press. https://doi.org/10.1385/1-59259-149-3:121

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  • DOI: https://doi.org/10.1385/1-59259-149-3:121

  • Publisher Name: Humana Press

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