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Protein-Polysaccharide Conjugation

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Part of the Methods in Molecular Medicine™ book series (MIMM,volume 66)

Abstract

The use of bacterial capsular polysaccharides as immunoprophylactic agents in human diseases caused by encapsulated bacteria is now firmly established (1). However, despite their many advantages, they do have serious limitations. First, they induce an inadequate immune response in infants (2), the section of the population most vulnerable to bacterial meningitis, and second, some polysaccharides are only weakly immunogenic in adults. To overcome these deficiencies, a new generation of semisynthetic vaccines have been developed based on the conjugation of polysaccharide to protein carriers.

Keywords

  • Bacterial Meningitis
  • Tetanus Toxoid
  • Reductive Amination
  • Sodium Periodate
  • Sodium Cyanoborohydride

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • DOI: 10.1385/1-59259-148-5:49
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References

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  4. Jennings, H. J. and Lugowski, C. (1981) Immunochemistry of group A, B and C meningococcal polysaccharide-tetanus toxoid conjugates. J. Immunol. 127, 1011–1018.

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© 2001 Humana Press Inc., Totowa, NJ

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Guo, Z., Jennings, H. (2001). Protein-Polysaccharide Conjugation. In: Pollard, A.J., Maiden, M.C. (eds) Meningococcal Vaccines. Methods in Molecular Medicine™, vol 66. Humana Press. https://doi.org/10.1385/1-59259-148-5:49

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  • DOI: https://doi.org/10.1385/1-59259-148-5:49

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-801-1

  • Online ISBN: 978-1-59259-148-0

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