Abstract
Throughout the 1990s, the incidence of meningococcal disease was higher in England and Wales than in most other European countries (1). In addition to the high incidence, the pattern of disease changed, with shifts to more cases caused by serogroup C strains, and more cases occurring in older teenagers, among whom the case fatality rate is higher than in any other age group (2,3). Not surprisingly, market research undertaken by the UK Health Education Authority consistently showed that meningococcal disease is the most feared disease by parents of young children (unpublished reports based on British Market Research Bureau surveys). By 1999, serogroup C accounted for 41% of laboratory confirmed cases; 49% were serogroup B (3).
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Connolly, M. and Noah, N. (1999) Is Group C meningococcal disease increasing in Europe? A report of surveillance of meningococcal infection in Europe 1993–6. European Meningitis Surveillance Group. Epidemiol. Infect. 122, 41–49.
Anonymous (1999) Enhanced surveillance of meningococcal disease. Commun. Dis. Rep. 9(30), 263–264.
Ramsay, M., Kaczmarski, E., Rush, M., Mallard, R., Farrington, P., and White, J. (1997) Changing patterns of case ascertainment and trends in meningococcal disease in England and Wales. Commun. Dis. Rep. Rev. 7, R49–R54.
Anonymous (1999) Vaccination program for group C meningococcal infection is launched. Commun. Dis. Rep. 9(30), 261, 264.
Slack, M. P., Azzopardi, H. J., Hargreaves, R. M., and Ramsay, M. E. (1998) Enhanced surveillance of invasive Haemophilus influenzae disease in England, 1990 to 1996; impact of conjugate vaccines. Pediatr. Infect. Dis. J. 7, S204–S207.
Richmond, P., Borrow, R., Miller, E., Clark, S., Sadler, F., Fox, A., et al. (1999) Meningococcal Serogroup C Conjugate Vaccine is immunogenic in Infancy and primes for memory. JID 179, 1569–1572.
Richmond, P., Borrow, R., Fox, A., Clark, S., Sadler, F., Morris, R., et al. (1999) Evaluation of meningococcal C conjugate vaccines in UK infants. Proceedings of the Royal College of Paediatrics and Child Health, Spring Meeting. Arch. Dis. Child. (Suppl.1), pA71.
Richmond, P., Cartwright, K., Borrow, R., Morris, R., Clark, S., Burrage, M., et al. (1998) An investigation of the immunogenicity and reactogenicity of three meningococcal serogroup C conjugate vaccines administered as a single dose in UK toddlers. Eleventh International Pathogenic Neisseria Conference. Paris, p. 156.
Richmond, P., Borrow, R., Clark, S., Findlow, J., Morris, R., Kaczmarski, E., et al. (1999) A single dose of meningococcal C conjugate vaccine is immunogenic and primes for memory in toddlers. Proceedings of the Royal College of Paediatrics and Child Health, Spring Meeting. Arch. Dis. Child. 80(Suppl.1), p. A73.
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© 2001 Humana Press Inc., Totowa, NJ
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Salisbury, D.M. (2001). The Introduction of Group C Conjugate Meningococcal Vaccine into the UK. In: Pollard, A.J., Maiden, M.C. (eds) Meningococcal Vaccines. Methods in Molecular Medicine™, vol 66. Humana Press. https://doi.org/10.1385/1-59259-148-5:395
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DOI: https://doi.org/10.1385/1-59259-148-5:395
Publisher Name: Humana Press
Print ISBN: 978-0-89603-801-1
Online ISBN: 978-1-59259-148-0
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