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Testing Meningococcal Vaccines for Mitogenicity and Superantigenicity

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Part of the Methods in Molecular Medicine™ book series (MIMM,volume 66)

Abstract

Proteins with intrinsic mitogenic properties are widely represented in prokaryotes, such as in different Streptococcus species (13), Candida albicans (4), and Eikenella corrodens (5). Specifically, several bacterial porins of Escherichia coli, Shigella dysenteriae, Salmonella typhimurium, Fusobacterium nucleatum, and pathogenic Neisseria species have been shown to induce nonspecific proliferation of lymphocytes (612).

Keywords

  • Spleen Cell
  • Complete RPMI
  • Polyclonal Activation
  • Antibiotic Medium
  • Porin Protein

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© 2001 Humana Press Inc., Totowa, NJ

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Delvig, A.A., Robinson, J.H., Wetzler, L. (2001). Testing Meningococcal Vaccines for Mitogenicity and Superantigenicity. In: Pollard, A.J., Maiden, M.C. (eds) Meningococcal Vaccines. Methods in Molecular Medicine™, vol 66. Humana Press. https://doi.org/10.1385/1-59259-148-5:199

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  • DOI: https://doi.org/10.1385/1-59259-148-5:199

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-801-1

  • Online ISBN: 978-1-59259-148-0

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