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Testing Meningococcal Vaccines for Mitogenicity and Superantigenicity

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Meningococcal Vaccines

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 66))

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Abstract

Proteins with intrinsic mitogenic properties are widely represented in prokaryotes, such as in different Streptococcus species (1–3), Candida albicans (4), and Eikenella corrodens (5). Specifically, several bacterial porins of Escherichia coli, Shigella dysenteriae, Salmonella typhimurium, Fusobacterium nucleatum, and pathogenic Neisseria species have been shown to induce nonspecific proliferation of lymphocytes (6–12).

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Newcastle University, Newcastle, UK

    Alexei A. Delvig & John H. Robinson

  2. Evans Biomedical Research Center, Boston University School of Medicine, Boston, MA

    Lee Wetzler

Authors
  1. Alexei A. Delvig
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  2. John H. Robinson
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  3. Lee Wetzler
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Editor information

Editors and Affiliations

  1. BC Research Institute for Children’s and Women’s Health, Vancouver, BC, Canada

    Andrew J. Pollard MD, PhD

  2. Wellcome Trust Centre for the Epidemiology of Infectious Disease, Oxford, UK

    Martin C.J. Maiden PhD

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© 2001 Humana Press Inc., Totowa, NJ

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Delvig, A.A., Robinson, J.H., Wetzler, L. (2001). Testing Meningococcal Vaccines for Mitogenicity and Superantigenicity. In: Pollard, A.J., Maiden, M.C. (eds) Meningococcal Vaccines. Methods in Molecular Medicine™, vol 66. Humana Press. https://doi.org/10.1385/1-59259-148-5:199

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  • DOI: https://doi.org/10.1385/1-59259-148-5:199

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-801-1

  • Online ISBN: 978-1-59259-148-0

  • eBook Packages: Springer Protocols

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