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Methods for Manipulation of Transferrin-Binding Proteins

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Meningococcal Vaccines

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 66))

Abstract

To obtain iron, a necessary nutrient, meningococci and several other human and veterinary pathogens have iron-acquisition systems, which are expressed in vivo during infection. One target of iron-acquisition systems is transferrin (Tf), which is the major glycoprotein responsible for the transport of iron in the extracellular milieu of vertebrates. Tf-binding proteins A and B (TbpA and TbpB) function as the cell-surface Tf receptor in Neisseria meningitidis (1).

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Author information

Authors and Affiliations

  1. Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, AB, Canada

    Leanne M. DeWinter & Anthony B. Schryvers

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  1. Leanne M. DeWinter
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  2. Anthony B. Schryvers
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Editor information

Editors and Affiliations

  1. BC Research Institute for Children’s and Women’s Health, Vancouver, BC, Canada

    Andrew J. Pollard MD, PhD

  2. Wellcome Trust Centre for the Epidemiology of Infectious Disease, Oxford, UK

    Martin C.J. Maiden PhD

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© 2001 Humana Press Inc., Totowa, NJ

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DeWinter, L.M., Schryvers, A.B. (2001). Methods for Manipulation of Transferrin-Binding Proteins. In: Pollard, A.J., Maiden, M.C. (eds) Meningococcal Vaccines. Methods in Molecular Medicine™, vol 66. Humana Press. https://doi.org/10.1385/1-59259-148-5:109

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  • DOI: https://doi.org/10.1385/1-59259-148-5:109

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-801-1

  • Online ISBN: 978-1-59259-148-0

  • eBook Packages: Springer Protocols

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