Dissection of Immunosuppressive Effects of Ultraviolet Radiation
For nearly 100 yr physicians and scientists have appreciated the carcinogenic potential of the ultraviolet (UV) radiation present in sunlight 0(1,2). During the latter part of the twentieth century, immunologists and dermatologists realized that UV radiation suppressed the immune response (3, 4, 5). Moreover, the immune suppression induced by UV radiation is a major risk factor for the induction of nonmelanoma skin cancer (6). The association between nonmelanoma skin cancer induction and immune suppression has fueled the efforts of many to study the immunologic mechanism underlying UV-induced immune suppression. This chapter focuses on describing the methods used to dissect the suppressive effects of UV on the immune system, concentrating particularly on in vivo models of immunity.
KeywordsToxicity Quartz Acetone Albumin Attenuation
- 1.Urbach, F.(1978) Evidence and epidemiology of UV-induced carcinogenesis in man. Natl. Cancer Inst. Monogr. 50, 5–10.Google Scholar
- 12.Moodycliffe, A. M., Maiti, S., and Ullrich, S. E. (1999) Splenic NK 1.1-negative, TCR intermediate CD4+ T cells exist in naive NK1.1 allelic positive and negative mice, with the capacity to rapidly secrete large amounts of IL-4 and IFN-γ upon primary TCR stimulation. J. Immunol. 162, 5156–5163.PubMedGoogle Scholar
- 14.Ullrich, S. E. (2000) The effects of ultraviolet radiation on the immune response, in Biochemical Modulation of Skin Reactions in Dermal and Transdermal Delivery of Drugs ]Kydonieus, A. F. and Wille, J. J., eds.), CRC Press, Boca Raton, FL, pp. 281–300.Google Scholar