Abstract
The classification of epithelial tumors of the kidney has undergone considerable change in the last two decades. Systems based on cytoplasmic characteristics and cytogenetic analysis have expanded our understanding of this group of tumors. These new, nontraditional systems have led to the development of a more clinically significant pathological classification (1,2). Although many questions remain unanswered and debate continues concerning the validity of these proposals, research studies on epithelial neoplasms of the kidney must take these advances into consideration. Scientific studies of any type should incorporate information regarding the type of tumor(s) included in the study group. This chapter briefly reviews the accepted subtypes of renal epithelial neoplasms, with a focus on the morphological features that distinguish them.
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References
Fleming, S. (1993) The impact of genetics on the classification of renal carcinoma. Histopathology22, 89–92.
Zambrano, N. R., Lubensky, I. A., Merino, M. J., Linehan, W. M., and Walther, M. M. (1999) Histopathology and molecular genetics of renal tumors: toward unification of a classification system. J. Urol.162, 1246–1258.
Thoenes, W., Störkel, S., and Rumpelt, H. J. (1986) Histopathology and classification of renal cell tumors (adenomas, oncocytomas, and carcinomas). Path. Res. Pract.181, 125–143.
Störkel, S., Eble, J. N., Adlakha, K., Amin, M., Blute, M. L., and Bostwick, D. G. (1997) Classification of renal cell carcinoma: workgroup 1. Cancer80, 987–989.
Kovacs, G., Akhtar, M., Beckwith, B. J., Bugert, P., Cooper, P., Cooper, C. S., Delahunt, B., Eble, J. N., Fleming, S., Ljungberg, B., Medeiros, L. J., Moch, H., Reuter, V. E., Ritz, E., Roos, G., Schmidt, D., Srigley, J. R., Störkel, S., van den Berg, E., and Zbar, B. (1997) The Heidelberg classification of renal cell tumors (editorial). J. Pathol.183, 131–133.
Kovacs, G. (1993) Molecular differential pathology of renal cell tumors. Histopathology2, 1–8.
Gnarra, J. R., Tory, K., Weng, Y., Schmidt, L., Wei, M. H., Li, H., Latif, F., Liu, S., Chen, F., and Duh, F. M. (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat. Genet.7, 85–90.
Schwerdtle, R. F., Störkel, S., Neuhaus, C., Brauch, H., Weidt, E., Brenner, W., Hohenfellner, R., Huber, C., and Decker, H. J. (1996) Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma. Cancer. Res.56, 2927–2930.
Grignon, D. J. and Eble, J. N. (1998) Papillary and metanephric adenomas of the kidney. Semin. Diagn. Pathol.15, 41–53.
Eble, J. and Warfel, K. (1991) Early human renal cortical epithelial neoplasia. Mod. Pathol.4, 45A.
Hughson, M. D., Buchwald, D., and Fox, M. (1986) Renal neoplasia and acquired cystic kidney disease in patients receiving long-term dialysis. Arch. Pathol. Lab. Med.110, 592–601.
Delahunt, B. and Eble, J. N. (1997) Papillary adenoma of the kidney: an evolving concept. J. Urological Pathol.7, 99–112.
Jones, E. C., Pins, M., Dickersin, R. D., and Young, R. H. (1995) Metanephric adenoma of the kidney: a clinicopathological, immunohistochemical, flow cytometric, cytogenetic and electron microscopic study of seven cases. Am. J. Surg. Pathol.19, 615–626.
Davis, C. J. Jr., Barton, J. H., Sesterhenn, I. A., and Mostofi, F. K. (1995) Metanephric adenoma: clinicopathological study of fifty patients. Am. J. Surg. Pathol.19, 1101–1114.
Gatalica, Z., Grujic, S., Kovatich, A., and Petersen, R. O. (1996) Metanephric adenoma: histology, immunophenotype, cytogenetics, ultrastructure. Mod. Pathol.9, 329–333.
Brown, J. A., Anderl, K. L., Borell, T. J., Qian, J., Bostwick, D. G., and Jenkins, R. B. (1997) Simultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence that renal metanephric adenoma is related to papillary renal cell carcinoma. J. Urol.158, 370–374.
Klein, M. J. and Valensi, Q. J. (1976) Proximal tubular adenomas of the kidney with so-called oncocytic features: a clinicopathologic study of 13 cases of a rarely reported neoplasm. Cancer38, 906–914.
Merino, M. J. and LiVolsi, V. A. (1982) Oncocytomas of the kidney. Cancer50, 1852–1856.
Barnes, C. A. and Beckman, E. N. (1983) Renal oncocytoma and its congeners. Am. J. Clin. Pathol.79, 312–318.
Amin, M. B., Crotty, T. B., Tickoo, S. K., and Farrow, G. M. (1997) Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am. J. Surg. Pathol.21, 1–12.
Lyzak, J. S., Farhood, A., and Verani, R. (1994) Intracytoplasmic lumens in renal oncocytoma and possible origin from intercalated cells of the collecting duct. J. Urol. Pathol.2, 135–151.
Warfel, K. A. and Eble, J. N. (1982) Renal oncocytomatosis. J. Urol.127, 1179–1180.
Slagel, D. and Bonsib, S. M. (1995) Renal oncocytoma with unusual features: case report and review of morphologic variants of oncocytoma. J. Urol. Pathol.3, 223–233.
Perez-Ordonez, B., Hamed, G., Campbell, S., Erlandson, R. A., Russo, P., Gaudin, P. B., and Reuter, V. E. (1997) Renal oncocytoma: a clinicopathologic study of 70 cases. Am. J. Surg. Pathol.21, 871–883.
DeLong, W. H., Sakr, W. A., and Grignon, D. J. (1996) Chromophobe renal cell carcinoma: a comparative histochemical and immunohistochemical study. J. Urol. Pathol. 4, 1–8.
Ogawa, O., Kakehi, Y., Ogawa, K., Koshiba, M., Sugiyama, T., and Yoshida, O. (1991) Allelic loss at chromosome 3p characterizes clear cell phenotype of renal cell carcinoma. Cancer. Res.51, 949–953.
Solomon, D. and Schwartz, A. (1988) Renal pathology in von Hippel-Lindau disease. Hum. Pathol.19, 1072–1079.
Washecka, R. and Hanna, M. (1991) Malignant renal tumors in tuberous sclerosis. Urology37, 340–343.
Fuhrman, S. A., Lasky, L. C., and Limas, C. (1982) Prognostic significance of morphologic parameters in renal cell carcinoma. Am. J. Surg. Pathol.6, 655–663.
Grignon, D. J., Ayala, A. G., El-Naggar, A. K., Wishnow, K. I., Ro, J. Y., Swanson, D. A., McLemore, D., Giacco, G. G., and Guinee, V. F. (1989) Renal cell carcinoma: a clinicopathologic and DNA flow cytometric analysis of 103 cases. Cancer64, 2133–2140.
El-Naggar, A. K., Ro, J. Y., and Ensigen, L. G. (1993) Papillary renal cell carcinoma: clinical implication of DNA content analysis. Hum. Pathol.24, 316–321.
Renshaw, A. A. and Corless, C. L. (1995) Papillary renal cell carcinoma: histology and immunohistochemistry. Am. J. Surg. Pathol.19, 842–849.
Delahunt, B. and Eble, J. N. (1997) Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. Mod. Pathol.10, 537–544.
Amin, M. B., Corless, C. L., Renshaw, A. A., Tickoo, S. K., Kubus, J., and Schultz, D. S. (1997) Papillary (chromophil) renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 62 cases. Am. J. Surg. Pathol.21, 621–635.
Kovacs, G. (1989) Papillary renal cell carcinoma: a morphologic and cytogenetic study of 11 cases. Am. J. Pathol.134, 27–34.
Van Den Berg, E., van der Hout, A. H., Oosterhuis, J. W., et al. (1993) Cytogenetic analysis of epithelial renal-cell tumours: rRelationship with a new histopathological classification. Int. J. Cancer55, 223–227.
Zbar, B., Glenn, G., Lubensky, I., Choyke, P., Walther, M. M., Magnusson, G., Bergerheim, U. S., Pettersson, S., Amin, M., and Hurley, K. (1995) Hereditary papillary renal cell carcinoma: clinical studies in 10 families. J. Urol.153, 907–912.
Schmidt, L., Duh, F. M., Chen, F., Kishida, T., Glenn, G., Choyke, P., Scherer, S. W., Zhuang, Z., Lubensky, I., Dean, M., Allikmets, R., Chidabaram, A., Bergerheim, U. R., Feltis, J. T., Casadevall, C., Zamarron, A., Bernues, M., Richard, S., Lips, C. J., Walther, M. M., Tsui, L. C., Geil, L., Orcutt, M. L., Stackhouse, T., and Zbar, B. (1997) Germline and somatic mutations in the tyrosine kinase domain of the MET protooncogene in papillary renal carcinomas. Nat. Genet.16, 68–73.
Hughson, M. D., Johnson, L. D., Silva, F. G., and Kovacs G. (1993) Nonpapillary and papillary renal cell carcinoma: a cytogenetic and phenotypic study. Mod. Pathol.6, 449–456.
Gatalica, Z., Kovatich, A., and Miettinen, M. (1995) Consistent expression of cytokeratin 7 in papillary renal-cell carcinoma: An immunohistochemical study in formalin-fixed, paraffin-embedded tissues. J. Urol. Pathol.3, 205–211.
Thoenes, W., Störkel, S., and Rumpelt, H.-J. (1985) Human chromophobe cell renal carcinoma. Virchows Arch. (Cell Pathol.)48, 207–217.
Akhtar, M., Kardar, H., Linjawi, T., McLintock, J., and Ali, M. A. (1995) Chromophobe cell carcinoma of the kidney: a clinicopathologic study of 21 cases. Am. J. Surg. Pathol.19, 1245–1256.
Thoenes, W., Störkel, S., Rumpelt, H.-J., Moll, R., Baum, H. P., and Werner, S. (1988) Chromophobe cell renal carcinoma and its variants—a report on 32 cases. J. Pathol.155, 277–287.
Störkel, S., Steart, P. V., Drenckhahn, D., and Thoenes, W. (1989) The human chromophobe cell renal carcinoma: its probable relation to intercalated cells of the collecting duct. Virchows Arch. (Cell Pathol.)56, 237–245.
Kovacs, A. and Kovacs, G. (1992) Low chromosome number in chromophobe renal cell carcinomas. Genes Chromosomes Cancer4, 267–268.
Speicher, M. R., Schoell, B., du Manoir, S., Schrock, E., Ried, T., Cremer, T., Störkel, S., Kovacs, A., and Kovacs, G. (1994) Specific loss of chromosomes 1,2,6,10,13,17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am. J. Pathol.145, 356–364.
Aizawa, S., Chigusa, M., Ohno, Y., and Suzuki, M. (1997) Chromophobe cell renal carcinoma with sarcomatoid component: a report of two cases. J. Urol. Pathol.6, 51–59.
Pitz, S., Moll, R., Störkel, S., and Thoenes, W. (1987) Expression of intermediate filament proteins in subtypes of renal cell carcinomas and in renal oncocytomas. Lab. Invest.56, 642–653.
Tickoo, S. K., Amin, M. B., and Zarbo, R. J. (1998) Colloidal iron staining in renal epithelial neoplasms, including chromophobe renal cell carcinoma: emphasis on technique and patterns of staining. Am. J. Surg. Pathol.22, 419–424.
GerHarz, C.-D., Moll, R., Störkel, S., Ramp, U., Thoenes, W., and Gabbert, H. E. (1993) Ultrastructural appearance and cytoskeletal architecture of the clear, chromophilic, and chromophobe types of human renal cell carcinoma in vitro. Am. J. Pathol.142, 851–859.
Mancilla-Jimenez, R., Stanley, R. J., and Blath, R. A. (1976) Papillary renal cell carcinoma. Cancer38, 2469–2480.
Fleming, S. and Lewi, H. J. E. (1986) Collecting duct carcinoma of the kidney. Histopathology10, 1131–1141.
Rumpelt, H. J., Störkel, S., Moll, R., Scharfe, T., and Thoenes, W. (1991) Bellini duct carcinoma: further evidence for this rare variant of renal cell carcinoma. Histopathology18, 115–122.
Srigley, J. R. and Eble, J. N. (1998) Collecting duct carcinoma of kidney. Semin. Diagn. Pathol.15, 54–67.
Dimopoulos, M. A., Logothetis, C. J., Markowitz, A., Sella, A., Amato, R., and Ro, J. Collecting duct carcinoma of the kidney. Br. J. Urol.71, 388–391.
Davis, C. J., Jr., Mostofi, F. K., and Sesterhenn, I. A. (1995) Renal medullary carcinoma: the seventh sickle cell nephropathy. Am. J. Surg. Pathol.19, 1–11.
MacLennan, G. T., Farrow, G. M., and Bostwick, D. G. (1997) Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of of possible collecting duct origin. Urology50, 679–684.
Gregori-Romero, M. A., Morell-Quadreny, L., and Llombart-Bosch, A. (1996) Cytogenetic analysis of three Bellini duct carcinomas. Genes Chromosomes Cancer15, 170–172.
Steiner, G., Cairns, P., Polascik, T. J., Marshall, F. F., Epstein, J. I., Sidransky, D., and Schoenberg, M. (1996) High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: region of minimal deletion at 1q32.1–32.2. CancerRes.56, 5044–5046.
Baer, S. C., Ro, J. Y., Ordonez, N. G., Maiese, R. L., Loose, J. H., Grignon, D. J., and Ayala, A. G. (1993) Sarcomatoid collecting duct carcinoma: a clinicopathologic and immunohistochemical study of five cases. Hum. Pathol.24, 1017–1022.
Kennedy, S. M., Merino, M. J., Linehan, W. M., Roberts, J. R., Robertson, C. N., and Neumann, R. D. (1990) Collecting duct carcinoma of the kidney. Hum. Pathol.21, 449–456.
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Grignon, D.J. (2001). Pathology of Kidney Tumors. In: Mydlo, J.H. (eds) Renal Cancer. Methods in Molecular Medicine, vol 53. Humana, Totowa, NJ. https://doi.org/10.1385/1-59259-144-2:035
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DOI: https://doi.org/10.1385/1-59259-144-2:035
Publisher Name: Humana, Totowa, NJ
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