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Pathology of Kidney Tumors

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Renal Cancer

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 53))

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Abstract

The classification of epithelial tumors of the kidney has undergone considerable change in the last two decades. Systems based on cytoplasmic characteristics and cytogenetic analysis have expanded our understanding of this group of tumors. These new, nontraditional systems have led to the development of a more clinically significant pathological classification (1,2). Although many questions remain unanswered and debate continues concerning the validity of these proposals, research studies on epithelial neoplasms of the kidney must take these advances into consideration. Scientific studies of any type should incorporate information regarding the type of tumor(s) included in the study group. This chapter briefly reviews the accepted subtypes of renal epithelial neoplasms, with a focus on the morphological features that distinguish them.

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References

  1. Fleming, S. (1993) The impact of genetics on the classification of renal carcinoma. Histopathology22, 89–92.

    CAS  PubMed  Google Scholar 

  2. Zambrano, N. R., Lubensky, I. A., Merino, M. J., Linehan, W. M., and Walther, M. M. (1999) Histopathology and molecular genetics of renal tumors: toward unification of a classification system. J. Urol.162, 1246–1258.

    CAS  PubMed  Google Scholar 

  3. Thoenes, W., Störkel, S., and Rumpelt, H. J. (1986) Histopathology and classification of renal cell tumors (adenomas, oncocytomas, and carcinomas). Path. Res. Pract.181, 125–143.

    CAS  PubMed  Google Scholar 

  4. Störkel, S., Eble, J. N., Adlakha, K., Amin, M., Blute, M. L., and Bostwick, D. G. (1997) Classification of renal cell carcinoma: workgroup 1. Cancer80, 987–989.

    PubMed  Google Scholar 

  5. Kovacs, G., Akhtar, M., Beckwith, B. J., Bugert, P., Cooper, P., Cooper, C. S., Delahunt, B., Eble, J. N., Fleming, S., Ljungberg, B., Medeiros, L. J., Moch, H., Reuter, V. E., Ritz, E., Roos, G., Schmidt, D., Srigley, J. R., Störkel, S., van den Berg, E., and Zbar, B. (1997) The Heidelberg classification of renal cell tumors (editorial). J. Pathol.183, 131–133.

    CAS  PubMed  Google Scholar 

  6. Kovacs, G. (1993) Molecular differential pathology of renal cell tumors. Histopathology2, 1–8.

    Google Scholar 

  7. Gnarra, J. R., Tory, K., Weng, Y., Schmidt, L., Wei, M. H., Li, H., Latif, F., Liu, S., Chen, F., and Duh, F. M. (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat. Genet.7, 85–90.

    CAS  PubMed  Google Scholar 

  8. Schwerdtle, R. F., Störkel, S., Neuhaus, C., Brauch, H., Weidt, E., Brenner, W., Hohenfellner, R., Huber, C., and Decker, H. J. (1996) Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma. Cancer. Res.56, 2927–2930.

    CAS  PubMed  Google Scholar 

  9. Grignon, D. J. and Eble, J. N. (1998) Papillary and metanephric adenomas of the kidney. Semin. Diagn. Pathol.15, 41–53.

    CAS  PubMed  Google Scholar 

  10. Eble, J. and Warfel, K. (1991) Early human renal cortical epithelial neoplasia. Mod. Pathol.4, 45A.

    Google Scholar 

  11. Hughson, M. D., Buchwald, D., and Fox, M. (1986) Renal neoplasia and acquired cystic kidney disease in patients receiving long-term dialysis. Arch. Pathol. Lab. Med.110, 592–601.

    CAS  PubMed  Google Scholar 

  12. Delahunt, B. and Eble, J. N. (1997) Papillary adenoma of the kidney: an evolving concept. J. Urological Pathol.7, 99–112.

    Google Scholar 

  13. Jones, E. C., Pins, M., Dickersin, R. D., and Young, R. H. (1995) Metanephric adenoma of the kidney: a clinicopathological, immunohistochemical, flow cytometric, cytogenetic and electron microscopic study of seven cases. Am. J. Surg. Pathol.19, 615–626.

    CAS  PubMed  Google Scholar 

  14. Davis, C. J. Jr., Barton, J. H., Sesterhenn, I. A., and Mostofi, F. K. (1995) Metanephric adenoma: clinicopathological study of fifty patients. Am. J. Surg. Pathol.19, 1101–1114.

    PubMed  Google Scholar 

  15. Gatalica, Z., Grujic, S., Kovatich, A., and Petersen, R. O. (1996) Metanephric adenoma: histology, immunophenotype, cytogenetics, ultrastructure. Mod. Pathol.9, 329–333.

    CAS  PubMed  Google Scholar 

  16. Brown, J. A., Anderl, K. L., Borell, T. J., Qian, J., Bostwick, D. G., and Jenkins, R. B. (1997) Simultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence that renal metanephric adenoma is related to papillary renal cell carcinoma. J. Urol.158, 370–374.

    CAS  PubMed  Google Scholar 

  17. Klein, M. J. and Valensi, Q. J. (1976) Proximal tubular adenomas of the kidney with so-called oncocytic features: a clinicopathologic study of 13 cases of a rarely reported neoplasm. Cancer38, 906–914.

    CAS  PubMed  Google Scholar 

  18. Merino, M. J. and LiVolsi, V. A. (1982) Oncocytomas of the kidney. Cancer50, 1852–1856.

    CAS  PubMed  Google Scholar 

  19. Barnes, C. A. and Beckman, E. N. (1983) Renal oncocytoma and its congeners. Am. J. Clin. Pathol.79, 312–318.

    CAS  PubMed  Google Scholar 

  20. Amin, M. B., Crotty, T. B., Tickoo, S. K., and Farrow, G. M. (1997) Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am. J. Surg. Pathol.21, 1–12.

    CAS  PubMed  Google Scholar 

  21. Lyzak, J. S., Farhood, A., and Verani, R. (1994) Intracytoplasmic lumens in renal oncocytoma and possible origin from intercalated cells of the collecting duct. J. Urol. Pathol.2, 135–151.

    Google Scholar 

  22. Warfel, K. A. and Eble, J. N. (1982) Renal oncocytomatosis. J. Urol.127, 1179–1180.

    CAS  PubMed  Google Scholar 

  23. Slagel, D. and Bonsib, S. M. (1995) Renal oncocytoma with unusual features: case report and review of morphologic variants of oncocytoma. J. Urol. Pathol.3, 223–233.

    Google Scholar 

  24. Perez-Ordonez, B., Hamed, G., Campbell, S., Erlandson, R. A., Russo, P., Gaudin, P. B., and Reuter, V. E. (1997) Renal oncocytoma: a clinicopathologic study of 70 cases. Am. J. Surg. Pathol.21, 871–883.

    CAS  PubMed  Google Scholar 

  25. DeLong, W. H., Sakr, W. A., and Grignon, D. J. (1996) Chromophobe renal cell carcinoma: a comparative histochemical and immunohistochemical study. J. Urol. Pathol. 4, 1–8.

    Google Scholar 

  26. Ogawa, O., Kakehi, Y., Ogawa, K., Koshiba, M., Sugiyama, T., and Yoshida, O. (1991) Allelic loss at chromosome 3p characterizes clear cell phenotype of renal cell carcinoma. Cancer. Res.51, 949–953.

    CAS  PubMed  Google Scholar 

  27. Solomon, D. and Schwartz, A. (1988) Renal pathology in von Hippel-Lindau disease. Hum. Pathol.19, 1072–1079.

    CAS  PubMed  Google Scholar 

  28. Washecka, R. and Hanna, M. (1991) Malignant renal tumors in tuberous sclerosis. Urology37, 340–343.

    CAS  PubMed  Google Scholar 

  29. Fuhrman, S. A., Lasky, L. C., and Limas, C. (1982) Prognostic significance of morphologic parameters in renal cell carcinoma. Am. J. Surg. Pathol.6, 655–663.

    CAS  PubMed  Google Scholar 

  30. Grignon, D. J., Ayala, A. G., El-Naggar, A. K., Wishnow, K. I., Ro, J. Y., Swanson, D. A., McLemore, D., Giacco, G. G., and Guinee, V. F. (1989) Renal cell carcinoma: a clinicopathologic and DNA flow cytometric analysis of 103 cases. Cancer64, 2133–2140.

    CAS  PubMed  Google Scholar 

  31. El-Naggar, A. K., Ro, J. Y., and Ensigen, L. G. (1993) Papillary renal cell carcinoma: clinical implication of DNA content analysis. Hum. Pathol.24, 316–321.

    CAS  PubMed  Google Scholar 

  32. Renshaw, A. A. and Corless, C. L. (1995) Papillary renal cell carcinoma: histology and immunohistochemistry. Am. J. Surg. Pathol.19, 842–849.

    CAS  PubMed  Google Scholar 

  33. Delahunt, B. and Eble, J. N. (1997) Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. Mod. Pathol.10, 537–544.

    CAS  PubMed  Google Scholar 

  34. Amin, M. B., Corless, C. L., Renshaw, A. A., Tickoo, S. K., Kubus, J., and Schultz, D. S. (1997) Papillary (chromophil) renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 62 cases. Am. J. Surg. Pathol.21, 621–635.

    CAS  PubMed  Google Scholar 

  35. Kovacs, G. (1989) Papillary renal cell carcinoma: a morphologic and cytogenetic study of 11 cases. Am. J. Pathol.134, 27–34.

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Van Den Berg, E., van der Hout, A. H., Oosterhuis, J. W., et al. (1993) Cytogenetic analysis of epithelial renal-cell tumours: rRelationship with a new histopathological classification. Int. J. Cancer55, 223–227.

    PubMed  Google Scholar 

  37. Zbar, B., Glenn, G., Lubensky, I., Choyke, P., Walther, M. M., Magnusson, G., Bergerheim, U. S., Pettersson, S., Amin, M., and Hurley, K. (1995) Hereditary papillary renal cell carcinoma: clinical studies in 10 families. J. Urol.153, 907–912.

    CAS  PubMed  Google Scholar 

  38. Schmidt, L., Duh, F. M., Chen, F., Kishida, T., Glenn, G., Choyke, P., Scherer, S. W., Zhuang, Z., Lubensky, I., Dean, M., Allikmets, R., Chidabaram, A., Bergerheim, U. R., Feltis, J. T., Casadevall, C., Zamarron, A., Bernues, M., Richard, S., Lips, C. J., Walther, M. M., Tsui, L. C., Geil, L., Orcutt, M. L., Stackhouse, T., and Zbar, B. (1997) Germline and somatic mutations in the tyrosine kinase domain of the MET protooncogene in papillary renal carcinomas. Nat. Genet.16, 68–73.

    CAS  PubMed  Google Scholar 

  39. Hughson, M. D., Johnson, L. D., Silva, F. G., and Kovacs G. (1993) Nonpapillary and papillary renal cell carcinoma: a cytogenetic and phenotypic study. Mod. Pathol.6, 449–456.

    CAS  PubMed  Google Scholar 

  40. Gatalica, Z., Kovatich, A., and Miettinen, M. (1995) Consistent expression of cytokeratin 7 in papillary renal-cell carcinoma: An immunohistochemical study in formalin-fixed, paraffin-embedded tissues. J. Urol. Pathol.3, 205–211.

    Google Scholar 

  41. Thoenes, W., Störkel, S., and Rumpelt, H.-J. (1985) Human chromophobe cell renal carcinoma. Virchows Arch. (Cell Pathol.)48, 207–217.

    CAS  Google Scholar 

  42. Akhtar, M., Kardar, H., Linjawi, T., McLintock, J., and Ali, M. A. (1995) Chromophobe cell carcinoma of the kidney: a clinicopathologic study of 21 cases. Am. J. Surg. Pathol.19, 1245–1256.

    CAS  PubMed  Google Scholar 

  43. Thoenes, W., Störkel, S., Rumpelt, H.-J., Moll, R., Baum, H. P., and Werner, S. (1988) Chromophobe cell renal carcinoma and its variants—a report on 32 cases. J. Pathol.155, 277–287.

    CAS  PubMed  Google Scholar 

  44. Störkel, S., Steart, P. V., Drenckhahn, D., and Thoenes, W. (1989) The human chromophobe cell renal carcinoma: its probable relation to intercalated cells of the collecting duct. Virchows Arch. (Cell Pathol.)56, 237–245.

    Google Scholar 

  45. Kovacs, A. and Kovacs, G. (1992) Low chromosome number in chromophobe renal cell carcinomas. Genes Chromosomes Cancer4, 267–268.

    CAS  PubMed  Google Scholar 

  46. Speicher, M. R., Schoell, B., du Manoir, S., Schrock, E., Ried, T., Cremer, T., Störkel, S., Kovacs, A., and Kovacs, G. (1994) Specific loss of chromosomes 1,2,6,10,13,17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am. J. Pathol.145, 356–364.

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Aizawa, S., Chigusa, M., Ohno, Y., and Suzuki, M. (1997) Chromophobe cell renal carcinoma with sarcomatoid component: a report of two cases. J. Urol. Pathol.6, 51–59.

    Google Scholar 

  48. Pitz, S., Moll, R., Störkel, S., and Thoenes, W. (1987) Expression of intermediate filament proteins in subtypes of renal cell carcinomas and in renal oncocytomas. Lab. Invest.56, 642–653.

    CAS  PubMed  Google Scholar 

  49. Tickoo, S. K., Amin, M. B., and Zarbo, R. J. (1998) Colloidal iron staining in renal epithelial neoplasms, including chromophobe renal cell carcinoma: emphasis on technique and patterns of staining. Am. J. Surg. Pathol.22, 419–424.

    CAS  PubMed  Google Scholar 

  50. GerHarz, C.-D., Moll, R., Störkel, S., Ramp, U., Thoenes, W., and Gabbert, H. E. (1993) Ultrastructural appearance and cytoskeletal architecture of the clear, chromophilic, and chromophobe types of human renal cell carcinoma in vitro. Am. J. Pathol.142, 851–859.

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Mancilla-Jimenez, R., Stanley, R. J., and Blath, R. A. (1976) Papillary renal cell carcinoma. Cancer38, 2469–2480.

    CAS  PubMed  Google Scholar 

  52. Fleming, S. and Lewi, H. J. E. (1986) Collecting duct carcinoma of the kidney. Histopathology10, 1131–1141.

    CAS  PubMed  Google Scholar 

  53. Rumpelt, H. J., Störkel, S., Moll, R., Scharfe, T., and Thoenes, W. (1991) Bellini duct carcinoma: further evidence for this rare variant of renal cell carcinoma. Histopathology18, 115–122.

    CAS  PubMed  Google Scholar 

  54. Srigley, J. R. and Eble, J. N. (1998) Collecting duct carcinoma of kidney. Semin. Diagn. Pathol.15, 54–67.

    CAS  PubMed  Google Scholar 

  55. Dimopoulos, M. A., Logothetis, C. J., Markowitz, A., Sella, A., Amato, R., and Ro, J. Collecting duct carcinoma of the kidney. Br. J. Urol.71, 388–391.

    Google Scholar 

  56. Davis, C. J., Jr., Mostofi, F. K., and Sesterhenn, I. A. (1995) Renal medullary carcinoma: the seventh sickle cell nephropathy. Am. J. Surg. Pathol.19, 1–11.

    PubMed  Google Scholar 

  57. MacLennan, G. T., Farrow, G. M., and Bostwick, D. G. (1997) Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of of possible collecting duct origin. Urology50, 679–684.

    CAS  PubMed  Google Scholar 

  58. Gregori-Romero, M. A., Morell-Quadreny, L., and Llombart-Bosch, A. (1996) Cytogenetic analysis of three Bellini duct carcinomas. Genes Chromosomes Cancer15, 170–172.

    CAS  PubMed  Google Scholar 

  59. Steiner, G., Cairns, P., Polascik, T. J., Marshall, F. F., Epstein, J. I., Sidransky, D., and Schoenberg, M. (1996) High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: region of minimal deletion at 1q32.1–32.2. CancerRes.56, 5044–5046.

    CAS  Google Scholar 

  60. Baer, S. C., Ro, J. Y., Ordonez, N. G., Maiese, R. L., Loose, J. H., Grignon, D. J., and Ayala, A. G. (1993) Sarcomatoid collecting duct carcinoma: a clinicopathologic and immunohistochemical study of five cases. Hum. Pathol.24, 1017–1022.

    CAS  PubMed  Google Scholar 

  61. Kennedy, S. M., Merino, M. J., Linehan, W. M., Roberts, J. R., Robertson, C. N., and Neumann, R. D. (1990) Collecting duct carcinoma of the kidney. Hum. Pathol.21, 449–456.

    CAS  PubMed  Google Scholar 

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Grignon, D.J. (2001). Pathology of Kidney Tumors. In: Mydlo, J.H. (eds) Renal Cancer. Methods in Molecular Medicine, vol 53. Humana, Totowa, NJ. https://doi.org/10.1385/1-59259-144-2:035

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  • DOI: https://doi.org/10.1385/1-59259-144-2:035

  • Publisher Name: Humana, Totowa, NJ

  • Print ISBN: 978-0-89603-828-8

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