Viral Liposomes

Preparation and Use
  • Yasufumi Kaneda
Part of the Methods in Molecular Medicine book series (MIMM, volume 69)

Abstract

With the aim of developing successful human gene therapy, numerous viral and nonviral (synthetic) methods of gene transfer have been developed (1,2), each method having limitations as well as advantages. To develop in vivo gene transfer vectors with high efficiency and low toxicity, several groups have attempted to overcome the limitations of one vector by combining them with the strengths of another.

Keywords

Cholesterol Cellulose Toxicity Sucrose DMSO 

References

  1. 1.
    Mulligan R. C. (1993) The basic science of gene therapy. Science 260, 926–932.PubMedCrossRefGoogle Scholar
  2. 2.
    Ledley F. D. (1995) Non-viral gene therapy: the promise of genes as pharmaceutical products. Hum. Gene Ther. 6, 1129–1144.PubMedCrossRefGoogle Scholar
  3. 3.
    Kaneda Y. (1998) Fusigenic Sendai-virus liposomes: a novel hybrid type lipo-some for gene therapy. Biogenic Amines 14, 553–572.Google Scholar
  4. 4.
    Kaneda Y., Saeki Y., Morishita R. (1999) Gene therapy using HVJ-liposomes; the best of both worlds. Mol. Med. Today 5, 298–303.PubMedCrossRefGoogle Scholar
  5. 5.
    Dzau V. J., Mann M., Morishita R., and Kaneda Y. (1996) Fusigenic viral lipo-some for gene therapy in cardiovascular diseases. Proc. Natl. Acad. Sci. USA 93, 11421–11425.PubMedCrossRefGoogle Scholar
  6. 6.
    Hirano T., Fujimoto J., Ueki T., et al. (1998) Persistent gene expression in rat liver in vivo by repetitive transfections using HVJ-liposome. Gene Ther. 5, 459–464.PubMedCrossRefGoogle Scholar
  7. 7.
    Saeki Y., Matsumoto N., Nakano Y., et al. (1997) Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): reciprocal effect of cationic lipid for in vitro and in vivo gene transfer. Hum. Gene Ther. 8, 1965–1972.CrossRefGoogle Scholar
  8. 8.
    Chander R. and Schreier H. (1992) Artificial viral envelopes containing recom-binant human immunodeficiency virus (HIV) gp160. Life Sci. 50, 481–489.PubMedCrossRefGoogle Scholar
  9. 9.
    Sawa Y., Kaneda Y., Bai H.-Z., et al. (1998) Efficient transfer of oligonucle-otides and plasmid DNA into the whole heart through the coronary artery. Gene Ther. 5, 1472–1480.PubMedCrossRefGoogle Scholar
  10. 10.
    Goyal K. and Huang L. (1995) Gene therapy using DC-Chol liposomes. J. Lipo-some Res. 5,49–60.CrossRefGoogle Scholar
  11. 11.
    Yamada G., Nakamura S., Haraguchi R., et al. (1997) An efficient liposome-mediated gene transfer into the branchial arch, neural tube and the heart of chick embryos: a strategy to elucidate organogenesis. Cell. Mol. Biol. 43, 1165–1169.PubMedGoogle Scholar
  12. 12.
    Yonemitsu Y., Kaneda Y., Muraishi A., et al. (1997) HVJ (Sendai virus)-cat-ionic liposomes: a novel and potentially effective liposome-mediated gene transfer technique to the delivery to the airway epithelium. Gene Ther. 4, 631–638.PubMedCrossRefGoogle Scholar
  13. 13.
    Mabuchi E., Shimizu K., Miyao Y., et al. (1997) Gene delivery by HVJ-liposome in the experimental gene therapy of murine glioma. Gene Ther. 4,768–772.PubMedCrossRefGoogle Scholar
  14. 14.
    Nishikawa T., Edelstein D., Du X.L., et al. (2000) Normalization of mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404, 787–790.PubMedCrossRefGoogle Scholar
  15. 15.
    Kaneda Y., Iwai K., and Uchida T. (1989) Increased expression of DNA cointroduced with nuclear protein in adult rat liver. Science 243, 375–379.PubMedCrossRefGoogle Scholar
  16. 16.
    Kaneda Y., Iwai K., and Uchida T. (1989) Introduction and expression of the human insulin gene in adult rat liver. J. Biol. Chem. 264, 12126–12129.PubMedGoogle Scholar
  17. 17.
    Kato K., Nakanishi M., Kaneda Y., Uchida T., and Okada Y. (1991) Expression of hepatitis B virus surface antigen in adult rat liver. J. Biol. Chem. 266, 3361–3364.PubMedGoogle Scholar
  18. 18.
    Tomita N., Morishita R., Higaki J., et al. (1996) In vivo gene transfer of insulin gene into neonatal rats by HVJ-liposome method resulted in sustained transgene expression. Gene Ther. 3,477–482.PubMedGoogle Scholar
  19. 19.
    Tomita N., Higaki J., Morishita R., et al. (1992) Direct in vivo gene introduction into rat kidney. Biochem. Biophys. Res. Commun. 186, 129–134.PubMedCrossRefGoogle Scholar
  20. 20.
    Isaka Y., Fujiwara Y., Ueda N., et al. (1993) Glomerulosclerosis induced by in vivo transfection with TGF-β or PDGF gene into rat kidney. J. Clin. Invest. 92, 2597–2601.PubMedCrossRefGoogle Scholar
  21. 21.
    Morishita R., Gibbons G., Kaneda Y., Ogihara T., and Dzau V. (1993) Novel and effective gene transfer technique for study of vascular renin angiotensin system. J. Clin. Invest. 91, 2580–2585.PubMedCrossRefGoogle Scholar
  22. 22.
    Okada Y. and Tadokoro J. (1962) Analysis of giant polynuclear cell formation caused by HVJ virus from Ehrlich’s ascites tumor cells. Exp. Cell Res. 26, 98128.Google Scholar
  23. 23.
    Suzuki K, Nakashima H, Sawa Y, et al. (2000) Reconstituted fusion liposomes for gene transfer in vitro and in vivo. Gene Ther. Reg. 1, 65–77.CrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • Yasufumi Kaneda
    • 1
  1. 1.Division of Gene Therapy ScienceGraduate School of MedicineSuita OsakaJapan

Personalised recommendations