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Metastasis Research Protocols pp 231–249Cite as

Transgenic Animal Models

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Part of the book series: Methods in Molecular Medicine ((MIMM,volume 58))

Abstract

Cancer is a prevalent and poorly understood disease in human populations. It is generally viewed as a complex, genetic, multistep process involving a series of independent events, each of which creates an incremental phenotypic aberration. For example, the capabilities for extended proliferation, invasion of adjacent tissue, and distant metastasis might each be acquired independently by a cancer cell (1-4). The molecular basis underlying the ability of tumor cells to metastasize from the primary site of growth to other tissues is a major challenge in understanding oncogenesis.

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Further Reading

  • Hogan, B., Beddington, R., Constantini, F., and Lacy, E. (1994) Manipulating the Mouse Embryo: A Laboratory Manual. 2nd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

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  • Murphy, D. and Carter, D. A., eds. (1993) Transgenesis Techniques: Principles and Protocols. Humana Press, Totowa, NJ.

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Author information

Authors and Affiliations

  1. Ardais Corporation, Lexington, MA, USA

    Chantale T. Guy & Gizela Cardoso

Authors
  1. Chantale T. Guy
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  2. Gizela Cardoso
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Editor information

Editors and Affiliations

  1. Research School of Biological and Molecular Sciences, Oxford Brookes University, Oxford, UK

    Susan A. Brooks

  2. Institute for Anatomy, Department of Neuroanatomy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

    Udo Schumacher

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© 2001 Humana Press Inc.

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Cite this protocol

Guy, C.T., Cardoso, G. (2001). Transgenic Animal Models. In: Brooks, S.A., Schumacher, U. (eds) Metastasis Research Protocols. Methods in Molecular Medicine, vol 58. Humana, Totowa, NJ. https://doi.org/10.1385/1-59259-137-X:231

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  • DOI: https://doi.org/10.1385/1-59259-137-X:231

  • Publisher Name: Humana, Totowa, NJ

  • Print ISBN: 978-0-89603-615-4

  • Online ISBN: 978-1-59259-137-4

  • eBook Packages: Springer Protocols

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