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Adhesion of Tumor Cells to Matrices and Endothelium

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Metastasis Research Protocols

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 58))

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Abstract

Cell adhesion is a process fundamental to tumor metastasis. Egress of cells from tumors and their entry into secondary tissues requires the regulated adhesion that underlies the process of cell migration. Thus, adhesion molecules must bind and release counter-receptors on the adhesive substrate in a controlled manner that permits locomotion (1-3). These same molecules must also interact in a complex manner with the intracellular actin cytoskeleton that is the motor for migration (1-3). In addition, it is now clear that there are interactions between adhesive counter receptors that do not mediate primary attachment to a substrate or support migration but are used to sample the adhesive microenvironment. Integration of “adhesive” signals with those from growth factors and cytokines may be used to regulate the pathophysiological responses of cells (1,4,5).

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Author information

Authors and Affiliations

  1. Cardiovascular Rheology Group, Department of Physiology, University of Birmingham Medical School, Birmingham, UK

    G. Ed Rainger

Authors
  1. G. Ed Rainger
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Editor information

Editors and Affiliations

  1. Research School of Biological and Molecular Sciences, Oxford Brookes University, Oxford, UK

    Susan A. Brooks

  2. Institute for Anatomy, Department of Neuroanatomy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

    Udo Schumacher

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© 2001 Humana Press Inc.

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Rainger, G.E. (2001). Adhesion of Tumor Cells to Matrices and Endothelium. In: Brooks, S.A., Schumacher, U. (eds) Metastasis Research Protocols. Methods in Molecular Medicine, vol 58. Humana, Totowa, NJ. https://doi.org/10.1385/1-59259-137-X:103

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  • DOI: https://doi.org/10.1385/1-59259-137-X:103

  • Publisher Name: Humana, Totowa, NJ

  • Print ISBN: 978-0-89603-615-4

  • Online ISBN: 978-1-59259-137-4

  • eBook Packages: Springer Protocols

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