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Clinically Accurate Orthotopic Mouse Models of Cancer

  • Robert M. Hoffman
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 58)

Abstract

In the past 10 years, we have developed a new approach to the development of a clinically accurate rodent model for human cancer based on our invention of surgical orthotopic implantation (SOI). The SOI models have been described in approx 70 publications (2-72) and in four patents.* SOI allows human tumors of all the major types of human cancer to reproduce clinical-like tumor growth and metastasis in the transplanted rodents (2-72). The major features of the SOI models are reviewed here and also compared to transgenic mouse models of cancer.

Keywords

Nude Mouse Bone Metastasis Human Prostate Cancer Surgical Suture Tumor Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2001

Authors and Affiliations

  • Robert M. Hoffman
    • 1
  1. 1.AntiCancer, Inc. and Department of SurgeryUniversity of CaliforniaSan Diego

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