Localization of ATP P2X Receptors

  • Xuenong Bo
  • Geoffrey Burnstock
Part of the Methods in Pharmacology and Toxicology book series (MIPT)


The biological effects of extracellular purine compounds were first observed 70 years ago (1). The first evidence that ATP might be a neurotransmitter came from the studies of sensory innervation in the 1950s (2). It was found that antidromic stimulation of sensory nerves led to vasodilatation of rabbit ear artery, which was accompanied by ATP release. In the early 1960s, a nonadrenergic, noncholinergic (NANC) neurotransmission was recognized in the autonomic nervous system. Early evidence indicated that the principal active substance released from at least some of these nerves was ATP (3). The concept of purinergic neurotransmission was proposed by Burnstock in 1972 (4). It is now recognized that ATP acts as a neurotransmitter, cotransmitter, or neuromodulator in many systems (5).


Radioligand Binding Assay Urinary Bladder Smooth Muscle Nickel Ammonium Sulfate Tungstosilicic Acid Benzamidine Hydrochloride 
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Copyright information

© Humana Press Inc., Totowa, NJ 2001

Authors and Affiliations

  • Xuenong Bo
    • 1
  • Geoffrey Burnstock
    • 1
  1. 1.Autonomic Neuroscience InstituteRoyal Free and University College Hospital Medical SchoolLondonUK

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