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Ion Channel Localization pp 57–73Cite as

Localization of ATP P2X Receptors

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Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

The biological effects of extracellular purine compounds were first observed 70 years ago (1). The first evidence that ATP might be a neurotransmitter came from the studies of sensory innervation in the 1950s (2). It was found that antidromic stimulation of sensory nerves led to vasodilatation of rabbit ear artery, which was accompanied by ATP release. In the early 1960s, a nonadrenergic, noncholinergic (NANC) neurotransmission was recognized in the autonomic nervous system. Early evidence indicated that the principal active substance released from at least some of these nerves was ATP (3). The concept of purinergic neurotransmission was proposed by Burnstock in 1972 (4). It is now recognized that ATP acts as a neurotransmitter, cotransmitter, or neuromodulator in many systems (5).

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Author information

Authors and Affiliations

  1. Autonomic Neuroscience Institute, Royal Free and University College Hospital Medical School, London, UK

    Xuenong Bo & Geoffrey Burnstock

Authors
  1. Xuenong Bo
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  2. Geoffrey Burnstock
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Editor information

Editors and Affiliations

  1. University of Michigan, Ann Arbor, MI

    Anatoli N. Lopatin

  2. Washington University Medical School, St. Louis, MO

    Colin G. Nichols

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© 2001 Humana Press Inc., Totowa, NJ

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Bo, X., Burnstock, G. (2001). Localization of ATP P2X Receptors. In: Lopatin, A.N., Nichols, C.G. (eds) Ion Channel Localization. Methods in Pharmacology and Toxicology. Humana Press. https://doi.org/10.1385/1-59259-118-3:57

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  • DOI: https://doi.org/10.1385/1-59259-118-3:57

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-833-2

  • Online ISBN: 978-1-59259-118-3

  • eBook Packages: Springer Protocols

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