SV40 Protocols pp 213-218 | Cite as

Binding of SV40 Large T Antigen to the Retinoblastoma Susceptibility Gene Product and Related Proteins

  • Juan Zalvide
  • James A. DeCaprio
  • Hilde Stubdal
Part of the Methods in Molecular Biology™ book series (MIMB, volume 165)


SV40 large T antigen (T-ag) is an oncoprotein that induces transformation of cells through the binding and inactivation of the p53 tumor suppressor protein and the retinoblastoma family of proteins. This chapter focuses on the interaction of T-ag with the product of the retinoblastoma susceptibility gene (pRB), and two related proteins, p107 and p130 (1-3).


Quiescent Cell African Green Monkey Sodium Vanadate SV40 Origin LxCxE Motif 
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Copyright information

© Humana Press Inc., Totowa, NJ 2001

Authors and Affiliations

  • Juan Zalvide
    • 1
  • James A. DeCaprio
    • 1
  • Hilde Stubdal
    • 1
  1. 1.Dana-Farber Cancer InstituteHarvard Medical SchoolBoston

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