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Capillary Affinity Gel Electrophoresis

  • Yoshinobu Baba
Part of the Methods in Molecular Biology™ book series (MIMB, volume 163)

Abstract

Many human genetic diseases are caused by small alterations in DNA sequence of specific gene(s) (1,2. Many different types of DNA mutations and polymorphisms are found to contribute to the alterations in the DNA sequence of disease-causing genes. These polymorphisms include sequence changes, such as the replacement of one or several nucleotides, the deletion or insertion of a sequence, differences in a variable number of tandem repeat locus (VNTR), and the instability in the numbers of tandem copies of microsatellite repeat elements (1. High-performance technologies need to be developed, for the highly selective recognition of the alterations in the sequence of genes, as new approaches for DNA diagnosis of human diseases are needed for high-throughput analysis

Keywords

Migration Time Affinity Ligand Immobilize Ligand Tandem Repeat Locus Free Ligand Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2001

Authors and Affiliations

  • Yoshinobu Baba
    • 1
  1. 1.CREST, Japan Science and Technology Corp., Department of Medicinal Chemistry, Faculty of Pharmaceutical SciencesUniversity of TokushimaTokushimaJapan

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