Solid Tumor Cancer Markers and Applications to Steroid Hormone Research

  • Marcia V. Fournier
  • Katherine J. Martin
  • Arthur B. Pardee
Part of the Methods in Molecular Biology™ book series (MIMB, volume 176)

Abstract

Steroid hormones bind to their specific nuclear receptor protein, which are bound to their DNA receptor motifs and become activated to turn on transcription of other genes (1). As an important example, estrogen binds to estrogen receptors (ERs) and activates the progesterone receptor gene (2). Similarly, testosterone binds to its receptor and activates the prostate specific antigen gene, PSA, and others (3).

Keywords

Vortex Estrogen MgCl2 Testosterone Tamoxifen 

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Copyright information

© Humana Press Inc. 2001

Authors and Affiliations

  • Marcia V. Fournier
    • 1
  • Katherine J. Martin
    • 2
  • Arthur B. Pardee
    • 1
  1. 1.Adult Oncology DivisionDana-Farber Cancer InstituteBoston
  2. 2.Cancergenomics Inc.Boston

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