Abstract
The literature is now replete with articles covering the use of biocatalysis, with two commercially available databases (1,2), each listing over 20,000 reports of reactions using biologically derived catalysts, and several texts which extensively cover the subject (3–7). Even the more specific subtopic, the utility of biocatalysis in the pharmaceutical industry, is the subject of recent reviews listing hundreds of references (8,9). With this presence in the literature, it is timely to describe how biocatalysis has been applied by a Process Development Group to the synthesis of a single pharmaceutical entity. Using the antifungal compound SCH56592 (Fig. 1, compound 1) as an example, this chapter will describe several biocatalytic approaches that were explored for the synthesis of key intermediates of this molecule. In keeping with the subject of this volume, the description will concentrate on the use of commercially available enzymes in organic solvents, although hydrolytic reactions and microbial reductions will also be briefly addressed for comparison and to complete the narrative.
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Morgan, B., Dodds, D.R., Homann, M.J., Zaks, A., Vail, R. (2001). Biocatalysis in Pharmaceutical Process Development SCH56592, A Case Study. In: Vulfson, E.N., Halling, P.J., Holland, H.L. (eds) Enzymes in Nonaqueous Solvents. Methods in Biotechnology, vol 15. Humana Press. https://doi.org/10.1385/1-59259-112-4:423
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