Abstract
Among the biocatalysts used in organic synthesis, lipases (triacylglycerol acyl hydrolases, E.C. 3.1.1.3) are the most frequently used. Because of their ability to discriminate between enantiomers and enantiotopic groups, they are utilized in kinetic resolutions of racemates and desymmetrizations of prostereogenic or meso-compounds to provide an easy access to enantiomerically pure building blocks (1-6). Protecting group techniques take advantage of the regioselectivity and chemoselectivity of lipase-catalyzed reactions (7-9).
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Theil, F. (2001). Enantioselective Lipase-Catalyzed Transesterifications in Organic Solvents. In: Vulfson, E.N., Halling, P.J., Holland, H.L. (eds) Enzymes in Nonaqueous Solvents. Methods in Biotechnology, vol 15. Humana Press. https://doi.org/10.1385/1-59259-112-4:277
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DOI: https://doi.org/10.1385/1-59259-112-4:277
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