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Enzymatic Acylation of α-Butylglucoside in Nonaqueous Media

  • Marie-Pierre Bousquet
  • René-Marc Willemot
  • Pierre Monsan
  • Emmanuel Boures
Part of the Methods in Biotechnology book series (MIBT, volume 15)

Abstract

There is a need to modify many cosmetic or pharmaceutical products so that their properties (bioavailibility, toxicity, liposolubility, and hydrosolubility) are optimized. This can be achieved through transportation by “carrier molecules” which can promote drug intake. The amphiphilic structure of α-butylglucoside makes it particularly efficient for such a purpose. α-Butylglucoside is produced on an industrial scale through enzymatic transglycosylation between maltose and butanol (1-3). This glucose derivative contains several reactive hydroxyl groups and can, therefore, be acylated by means of lipase-catalyzed reactions (4). The advantage of α-butylglucoside over glucose is that the butanol moiety of α-butylglucoside helps the molecule to dissolve in apolar media, which are usually recommended for optimal lipase activity and stability (5-7).

Keywords

Linoleic Acid Commercial Mixture HPLC Chromatography Linolenic Acid Concentration Amphiphilic Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2001

Authors and Affiliations

  • Marie-Pierre Bousquet
    • 1
  • René-Marc Willemot
    • 1
  • Pierre Monsan
    • 1
  • Emmanuel Boures
    • 2
  1. 1.Centre de Bioingenierie Gilbert DurandToulouse CedexFrance
  2. 2.LILICE,Zac “Les Partes de Riom,” RiomFrance

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