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Isolated Resistance Artery Preparation

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Angiotensin Protocols

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 51))

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Abstract

The blood vessels that contribute most to precapillary resistance are known as resistance arteries, consisting of arterioles and small arteries with diameters of less than 500 μm (1). These vessels regulate the vascular resistance, and thus the blood supply, through the adjustment of their lumen diameter, which is accomplished by modulation of the level of tone in the vascular smooth muscle cells. The smooth muscle and endothelial cells in the blood vessel wall are sensitive to a great diversity of stimuli including distending pressure, shear stress, neurohumoral factors, and metabolites. All of these different signals are sensed, integrated, and eventually lead to a response.

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Authors and Affiliations

  1. Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA

    Jos P. M. Wesselman, Paul H. Ratz & Russell L. Prewitt

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  1. Jos P. M. Wesselman
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  2. Paul H. Ratz
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  3. Russell L. Prewitt
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  1. Department of Medicine, Michigan State University, East Lansing, MI

    Donna H. Wang

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© 2001 Humana Press Inc.

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Wesselman, J.P.M., Ratz, P.H., Prewitt, R.L. (2001). Isolated Resistance Artery Preparation. In: Wang, D.H. (eds) Angiotensin Protocols. Methods in Molecular Medicine™, vol 51. Humana Press. https://doi.org/10.1385/1-59259-087-X:471

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  • DOI: https://doi.org/10.1385/1-59259-087-X:471

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-763-2

  • Online ISBN: 978-1-59259-087-2

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