Abstract
The proximal tubules play a critical role in providing the kidneys with their ability to regulate body fluid volume and electrolyte composition. One major function is the reabsorption of sodium and other electrolytes which is caused, in part, by angiotensin II (Ang II), a peptide that is made up of eight amino acids. By activating Ang II receptors on both the basolateral and luminal membranes, Ang II serves a major function in determining how the kidney processes
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Navar, L. G., Harrison-Bernard, L. M., and Imig, J. D. (1998) Compartmentaliza-tion of intrarenal angiotensin II, in Renin-Angiotensin (Ulfendahl, H. R. and Aurell, M., eds.), Portland, London, pp. 193ā208.
Navar, L. G., Imig, J. D., Zou, L., and Wang, C. T. (1997) Intrarenal production of angiotensin II. Semin. Nephrol. 17, 412ā422.
Braam, B., Mitchell, K. D., Fox, J., and Navar, L. G. (1993) Proximal tubular secretion of angiotensin II in rats. Am. J. Physiol. 264, F891āF898.
Navar, L. G., Lewis, L., Hymel, A., Braam, B., and Mitchell, K. D. (1994) Tubular fluid concentrations and kidney contents of angiotensins I and II in anesthetized rats. J. Am. Soc. Nephrol. 5, 1153ā1158.
Seikaly, M. G., Arant Jr., B. S., and Seney Jr., F. D. (1990) Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J. Clin. Invest. 86, 1352ā1357.
Fox, J., Guan, S., Hymel, A. A., and Navar, L. G. (1992) Dietary Na and ACE inhibition effects on renal tissue angiotensin I and II and ACE activity in rats. Am. J. Physiol. 262, F902āF909.
Zou, L. X., Hymel, L. X., Imig, J. D., and Navar, L. G. (1996) Renal accumulation of circulating angiotensin II in angiotensin II-infused rats. Hypertension 27, 658ā662.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
Ā© 2001 Humana Press Inc.
About this protocol
Cite this protocol
Imig, J.D., Gabriel Navar, L. (2001). Measurement of Renal Tubular Angiotensin II. In: Wang, D.H. (eds) Angiotensin Protocols. Methods in Molecular Medicineā¢, vol 51. Humana Press. https://doi.org/10.1385/1-59259-087-X:427
Download citation
DOI: https://doi.org/10.1385/1-59259-087-X:427
Publisher Name: Humana Press
Print ISBN: 978-0-89603-763-2
Online ISBN: 978-1-59259-087-2
eBook Packages: Springer Protocols