Abstract
The transforming growth factor β (TGF-β) receptors are an important class of tumor suppressor gene. TGF-β markedly inhibits the growth of many epithelial cell types; whereas in contrast, cancers of many different tissue types are commonly TGF-β resistant (10). Many cancer cell lines are resistant to the growth suppressive effects of TGF-β and display evidence of disruption of TGF-β signal transduction (10,4,10). To date, this resistance appears to often result from mutations in the TGF-β receptors or the smad family of TGF-β signaling proteins (5,11,12,14,16).
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© 2001 Humana Press Inc.
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Grady, W.M., Myeroff, L.L., He, H., Markowitz, S. (2001). Mutation Detection inTGF-β Receptors. In: M., S. (eds) Colorectal Cancer. Methods in Molecular Medicine, vol 50. Humana Press. https://doi.org/10.1385/1-59259-084-5:99
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DOI: https://doi.org/10.1385/1-59259-084-5:99
Publisher Name: Humana Press
Print ISBN: 978-0-89603-767-0
Online ISBN: 978-1-59259-084-1
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