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Freund's Adjuvants

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Book cover Vaccine Adjuvants

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 42))

Abstract

Freund’s adjuvants are water-in-mineral oil emulsions (W/O emulsions) without heat-killed mycobacteria added (Freund’s incomplete adjuvant) or with heat-killed mycobacteria added (Freund’s complete adjuvant). Freund’s adjuvants are, in a way, historic adjuvants and for many researchers the first and most obvious association to the word adjuvant at all. The adjuvants have been used extensively in experimental immunology owing to their high efficacy, and Freund’s incomplete adjuvant has been used for decades in practical veterinary vaccination. Vaccination of humans with Freund’s incomplete adjuvant was undertaken in the 1950s and was stopped because of adverse reactions in the mid-1960s.

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Authors and Affiliations

  1. Superfos Biosector, Production, Frederikasund, Denmark

    Erik B. Lindblad

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  1. Erik B. Lindblad
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  1. Chiron Corporation, Emeryville, CA

    Derek T. O’Hagan

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© 2000 Humana Press Inc.

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Lindblad, E.B. (2000). Freund's Adjuvants. In: O’Hagan, D.T. (eds) Vaccine Adjuvants. Methods in Molecular Medicine™, vol 42. Springer, Totowa, NJ. https://doi.org/10.1385/1-59259-083-7:49

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  • DOI: https://doi.org/10.1385/1-59259-083-7:49

  • Publisher Name: Springer, Totowa, NJ

  • Print ISBN: 978-0-89603-735-9

  • Online ISBN: 978-1-59259-083-4

  • eBook Packages: Springer Protocols

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