Restriction Fragment End Labeling Analysis: High-Resolution Genomic Typing of Streptococcus pneumoniae Isolates

  • Peter W. M. Hermans
  • Marcel Sluijter
  • Alex van Belkum
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 48)


Streptococcus pneumoniae (pneumococcus) is one of the leading bacterial pathogens causing illness and death among young children, the elderly, and persons with certain underlying medical conditions (1). Pneumococci are often part of the normal nasopharyngeal flora, especially in young children. Pneumococcal colonization is an important risk factor: children colonized with S. pneumoniae more often develop acute otitis media than children who are not colonized (2-5).


Acute Otitis Medium Unweighted Pair Group Method With Arithmetic Average Geiger Counter Underlying Medical Condition Actinobacillus Actinomycetemcomitans 
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Copyright information

© The Humana Press Inc., Totowa, NJ 2001

Authors and Affiliations

  • Peter W. M. Hermans
    • 1
  • Marcel Sluijter
    • 1
  • Alex van Belkum
    • 2
  1. 1.Department of PaediatricsErasmus University Medical Center RotterdamRotterdamdamThe Netherlands
  2. 2.Department of Medical Microbiology and Infectious DiseasesErasmus University Medical Center RotterdamRotterdamThe Netherlands

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