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Antibodies for Neoplastic Disease

Solid Tumors

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Book cover Diagnostic and Therapeutic Antibodies

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 40))

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Abstract

The ease with which polyclonal, monoclonal, and engineered antibody fragments can be prepared allows access to a series of reagents with high selectivity and affinity. These reagents therefore have long held promise as a means of influencing the growth and spread of malignant disease. Over a number of decades therapeutic antibodies have been developed either as single entities or conjugated to a variety of potential disease-ameliorating agents.

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References

  1. Liu, S. Y. and Press, O. W. (1997) The potential for immunoconjugates in lym-phoma therapy. Haematol. Oncol. Clin. North Am.11, 987–1006.

    CAS  Google Scholar 

  2. Frankel, A. E., Laver, J. H., Willingham, M. C., Burns, L. J., Kersey, J. H., and Vallera, D. A. (1997) Therapy of patients with T-cell lymphomas and leukemias using an anti-CD7 monoclonal antibody-ricin A chain immunotoxin. Leuk. Lym-phoma26, 287–298.

    CAS  Google Scholar 

  3. LoRusso, P. M., Lomen, P. L., Redman, B. G., Poplin, E., Bander, J. J., and Valdivieso, M. (1995) Phase I study of monoclonal antibody-ricin A chain immunoconjugate Xomazyme-791 in patients with metastatic colon cancer. Am. J. Clin. Oncol.18, 307–312.

    CAS  PubMed  Google Scholar 

  4. Laske, D. W., Muraszko, K. M., Oldfield, E. H., DeVroom, H. L., Sung, C., Dedrick, R. L. Simon, T. R., Clandrea, J., Copeland, C., Katz, D., Greenfield, L., Groves, E. S., Houston, L. L., and Youle, R. J. (1997) Intraventricular immun-otoxin therapy for leptomeningeal neoplasia. Neurosurgery41, 1039–1049.

    CAS  PubMed  Google Scholar 

  5. Chen, S. Y., Yang, A. G., Chen, J. D., Kute, T., King, C. R., Collier, J., Cong, Y., Yao, C., and Huang, X. F. (1997) Potent antitumour activity of a new class of tumour-specific killer cells. Nature385, 78–80.

    CAS  PubMed  Google Scholar 

  6. Yarranton, G. (1998) Antibody-calicheamicin conjugates for the treatment of cancer. Antibody Engineering. New Technology, Application and Commercialisation. IBC event code IB 146. March 2-3, The Royal Society, London, UK.

    Google Scholar 

  7. Liu, C., Tadayoni, B. M., Bourret, L. A., Mattocks, K. M., Derr, S. M., Widdison, W. C., Kedersha, N. L., Ariniello, P. D., Goldmacher, V. S., Lambert, J. M., Blattler, W. A., and Chari, R. V. (1996) Eradication of large colon tumor xenografts by targeted delivery of maytansinoids. Proc. Natl. Acad. Sci. USA93(16), 8618–8623.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Press, O. W., Eary, J. F., Appelbaum, F. R., Martin, P. J., Badger, C. C., Nelp, W. B., Glenn, S., Butchko, G., Fisher, D., Porter, B., Matthews, D. C., Fisher, L. D., and Bernstein, I. D. (1993) Radiolabelled-antibody therapy of B-cell lymphoma with autologous bone marrow support. N. Engl. J. Med.329, 1219–1224.

    CAS  PubMed  Google Scholar 

  9. Goldenberg, D. M., ed. (1995) Cancer Therapy with Radiolabelled Antibodies. CRC, Boca Raton, FL.

    Google Scholar 

  10. Blumenthal, R. D., Sharkey, R. M., Natale, A. M., Kashi, R., Wong, G., and Goldenberg, D. M. (1994) Comparison of equitoxic radioimmunotherapy and chemotherapy in the treatment of human colonic cancer xenografts. Cancer Res.54, 142–151.

    CAS  PubMed  Google Scholar 

  11. Hird, V., Maraveyas, A., Snook, D., Dhokia, B. Soutter, W. P., Meares, C., Stewart, J. S., Mason, P., Lambert, H. E., and Epenetos, A. A. (1993) Adjuvant therapy of ovarian cancer with radioactive monoclonal antibody. Br. J. Cancer68(2), 403–406.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Canevari, S., Miotti, S., Bottere, F., Valota, O., and Colnaghi, M. I. (1993) Ovarian carcinoma therapy with monoclonal antibodies. Hybridoma12, 501–507.

    CAS  PubMed  Google Scholar 

  13. Riva, P., Tison, V., Arista, A., et al. (1993) Radioimmunotherapy of gastrointestinal cancer and glioblastomas. Int. J. Biol. Markers8, 192–197.

    CAS  PubMed  Google Scholar 

  14. Welt, S., Divgi, C. R., Kemeny, N., et al. (1994) Phase I/II study of iodine 131-labelled monoclonal antibody A3 3 in patients with advanced colon cancer. J. Clin. Oncol.12, 1561–1571.

    CAS  PubMed  Google Scholar 

  15. Riva, P., Arista, A., Tison, V., et al. (1994) Intralesional radioimmunotherapy of malignant glioma. An effective treatment in recurrent tumours. Cancer73, 1076–1082.

    CAS  PubMed  Google Scholar 

  16. Kalofonos, H. P., Pawlikowska, T. R., Hemingway, A., et al. (1989) Antibody guided diagnosis and therapy of brain gliomas using radiolabelled monoclonal antibodies against epidermal growth factor receptor and placental alkaline phos-phatase. J. Nucl. Med.30, 1636–1645.

    CAS  PubMed  Google Scholar 

  17. Grana, C., Chinol, M., Magnani, P., Corti, A., Sidoli, A., Siccardi, A. G., and Paganelli, G. (1996) In vivo tumour targeting based on the avidin-biotin system. Tumour Targeting2, 230–239.

    Google Scholar 

  18. Stillwagon, G. B., Order, S. E., Klein, J. L., et al. (1987) Multi-modality treatment of primary nonresectable intrahepatic cholangiocarcinoma with I-131 anti-CEA: a Radiation Therapy Oncology Group Study. Int. J. Radiat. Oncol. Biol. Phys.13, 687–695.

    Article  CAS  PubMed  Google Scholar 

  19. Order, S. E., Stillwagon, G. B., Klein, J. L., et al. (1985) Iodine-131-antiferritin, a new treatment modality in hepatoma: a Radiation Therapy Oncology Group Study. J. Clin. Oncol.3, 1573–1582.

    Article  CAS  PubMed  Google Scholar 

  20. Order, S. E., Vriesendorp, H. M., Klein, J. L., and Leichner, P. K. (1988) A phase I study of 90yttrium antiferritin: dose escalation and tumour dose. Antibody Immunoconj. Radiopharm.1, 163–168.

    Google Scholar 

  21. Zeng, Z. C., Tang, Z. Y., Xie, H., et al. (1993) Radioimmunotherapy for unresectable hepatocellular carcinoma using 131-Hepama-1 mAb: preliminary results. J. Cancer Res. Clin. Oncol.119, 257–259.

    CAS  PubMed  Google Scholar 

  22. Siegel, J. A., Pawlyk, D. A., Lee, R. E., et al. (1990) Tumor, red marrow and organ dosimetry for 131I-labelled anti-carcinoembryonic antigen monoclonal antibody. Cancer Res.50, 1039s–1042s.

    CAS  PubMed  Google Scholar 

  23. Thirion, S., Motmans, K., Heyligen, H., Janssens, J., Raus, J., and Vandevyver, C. (1997) Mono-and bispecific single-chain antibody fragments for cancer therapy. Euro. J. Can. Prev.5, 507–511.

    Google Scholar 

  24. Canevari, S., Stoter, G., Arienti, F., Bolis, G., Colnaghi, M. I., Di Re, E. M., and Eggermont, A. A. (1995) Regression of advanced ovarian carcinoma by intraperi-toneal treatment with autologous T lymphocytes retargeted by a bispecific antibody. J. Natl. Cancer Inst.87, 1463–1469.

    CAS  PubMed  Google Scholar 

  25. Valone, F. H., Kaufman, P. A., Guyre, P. M., Lewis, L. D., Memoli, V. Deo, Y., Graziano, R., Fisher, J. L., Meyer, L., Mrozek-Orlowski, M., et al. (1995) Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that over-expresses the proto-oncogene HER-2/neu. J. Clin. Oncol.13, 2281–2292.

    CAS  PubMed  Google Scholar 

  26. Riethmuller, G., Schneider-Gadicke, E., Schlimok, G., Schmiegel, W., Raab, R., Hoffken, K., Gruber, R., Pichlmaier, H., Hirche, H., Pichlmyr, R., et al. (1994) Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes’ C colorectal carcinoma. German Cancer Aid 17-1A Study Group. Lancet343, 1177–1183.

    CAS  PubMed  Google Scholar 

  27. Jerne, N. K. (1974) Towards a network theory of the immune system. Ann. Immunol. C25, 373–389.

    Google Scholar 

  28. Mittleman, A., Chen, Z. J., Kageshita, T., Yang, H., Yamada, M., Baskind, P., Goldberg, N., Ahmed, T., and Arlin, Z. (1990) Active specific immunotherapy in patients with melanoma. A clinical trial with mouse antiidiotypic monoclonal antibodies elicited with syngeneic anti-high-molecular-weight-melanoma-associated antigen monoclonal antibodies. J. Clin. Invest.86, 2136–2144.

    Google Scholar 

  29. Mittelman, A., Wang, X., Matsumoto, K., and Ferrone, S. (1995) Antiidiotypic response and clinical course of the disease in patients with malignant melanoma immunized with mouse antiidiotypic monoclonal antibody MK2-23. Hybridoma14, 175–181.

    CAS  PubMed  Google Scholar 

  30. Frodin, J. E., Faxas, M. E., Hagstrom, B., Lefvert, A. K., Masucci, G., Nilsson, B., Steinitz, M., Unger, P., and Mellstedt, H. (1991) Induction of anti-idiotypic (ab2) and anti-anti-idiotypic (ab3) antibodies in patients treated with the mouse monoclonal antibody 17-1A (ab1). Relation to the clinical outcome-an important antitumoral effector function? Hybridoma4, 421–431.

    Google Scholar 

  31. Madiyalakan, R., Sykes, T. R., Dharampaul, S., Sykes, C. J., Baum, R. P., Hor, G., and Noujaim, A. A. (1995) Antiidiotypic induction therapy: evidence for the induction of immune response through the idiotype network in patients with ovarian cancer after administration of anti-CA125 murine monoclonal antibody B43.13. Hybridoma14, 199–203.

    CAS  PubMed  Google Scholar 

  32. Durrant, L. G., Buckley, T. J., Denton, G. W., Hardcastle, J. D., Sewell, H. F., and Robins, R. A. (1994) Enhanced cell-mediated tumor killing in patients immunized with human monoclonal antiidiotypic antibody 105AD7. Cancer Res.54, 4837–4840.

    CAS  PubMed  Google Scholar 

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© 2000 Humana Press Inc.

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Matthews, I.T.W. (2000). Antibodies for Neoplastic Disease. In: George, A.J.T., Urch, C.E. (eds) Diagnostic and Therapeutic Antibodies. Methods in Molecular Medicine, vol 40. Humana, Totowa, NJ. https://doi.org/10.1385/1-59259-076-4:73

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  • DOI: https://doi.org/10.1385/1-59259-076-4:73

  • Publisher Name: Humana, Totowa, NJ

  • Print ISBN: 978-0-89603-798-4

  • Online ISBN: 978-1-59259-076-6

  • eBook Packages: Springer Protocols

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