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Animal Models for Tumor Localization

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Diagnostic and Therapeutic Antibodies

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 40))

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Abstract

Many factors influence the uptake of radiolabeled monoclonal antibodies (mAbs) in tumors. Some are dependent on the antibody, such as affinity, intact immunoglobulin or fragment, route of administration, choice of radio isotope, or method of labeling. Others depend on properties of the tumor, such as site, size, vasculature, and antigen density on the tumor cell surface. Animal models for studying these parameters are usually based on mice or rats bearing transplanted tumors. In this chapter, various tumor model systems will be described with some discussion of what data can be obtained using them.

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Authors and Affiliations

  1. Antisoma Research Laboratories, St. George’s Hospital Medical School, London, UK

    Gail Rowlinson-Busza

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  1. Gail Rowlinson-Busza
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Editors and Affiliations

  1. Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, UK

    Andrew J. T. George

  2. Department of Pharmacology, University College, London, UK

    Catherine E. Urch

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© 2000 Humana Press Inc.

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Rowlinson-Busza, G. (2000). Animal Models for Tumor Localization. In: George, A.J.T., Urch, C.E. (eds) Diagnostic and Therapeutic Antibodies. Methods in Molecular Medicine, vol 40. Humana, Totowa, NJ. https://doi.org/10.1385/1-59259-076-4:193

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  • DOI: https://doi.org/10.1385/1-59259-076-4:193

  • Publisher Name: Humana, Totowa, NJ

  • Print ISBN: 978-0-89603-798-4

  • Online ISBN: 978-1-59259-076-6

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