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Antibodies for Transplantation

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Diagnostic and Therapeutic Antibodies

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 40))

Abstract

The use of antibodies in transplantation has become a clinical reality. Antibodies have been used to both dampen the recipient’s immune response and to obscure the immunogenicity of the donor graft. Traditionally, antibodies have been administered to the transplant recipient to transiently inactivate the host’s T cells, the lymphocytes responsible for recognizing and attacking foreign proteins, cells, and tissues. Antibodies can also be used to eliminate any highly immunogenic passenger cells from a donor graft prior to transplantation, and antibodies can mask or conceal antigens present on donor cells that might trigger rejection.

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Author information

Authors and Affiliations

  1. Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts General Hospital, Charlestown, MA

    Denise L. Faustman

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  1. Denise L. Faustman
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Editors and Affiliations

  1. Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, UK

    Andrew J. T. George

  2. Department of Pharmacology, University College, London, UK

    Catherine E. Urch

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© 2000 Humana Press Inc.

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Faustman, D.L. (2000). Antibodies for Transplantation. In: George, A.J.T., Urch, C.E. (eds) Diagnostic and Therapeutic Antibodies. Methods in Molecular Medicine, vol 40. Humana, Totowa, NJ. https://doi.org/10.1385/1-59259-076-4:141

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  • DOI: https://doi.org/10.1385/1-59259-076-4:141

  • Publisher Name: Humana, Totowa, NJ

  • Print ISBN: 978-0-89603-798-4

  • Online ISBN: 978-1-59259-076-6

  • eBook Packages: Springer Protocols

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