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Drug Targeting pp 133-157 | Cite as

Inhibition of Tumor Blood Flow

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Part of the Methods in Molecular Medicine™ book series (MIMM, volume 25)

Abstract

Research into the treatment of cancer has often been driven by the idea that a common biochemical pathway might exist in all tumors, providing an ideal target for therapy. However, it is now clear that a great variety of genetic changes contributes to the development of individual cancers, and that no two cancers are identical. Nevertheless, a common feature in solid tumors is the disorganized way in which the blood vessels develop. Networks of tumor capillaries, linked to the blood supply by arterioles and venules, are necessary for tumors to grow but, in contrast to capillaries supplying normal tissue, are haphazard in both their structure and their dynamics. It may be possible to use this common feature as a basis for selective therapy. In this chapter we provide a short review of the vasculature of solid tumors, then describe methods by which drugs might be used to inhibit tumor blood flow. Finally, we review some of the methods available for measurement of tumor blood flow.

Keywords

Arterial Input Function Vinca Alkaloid Murine Tumor Tumor Blood Flow Absolute Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2000

Authors and Affiliations

  1. 1.Cancer Research LaboratoryUniversity of Auckland School of MedicineAucklandNew Zealand
  2. 2.Section of Oncology, Department of PathologyUniversity of Auckland School of MedicineAucklandNew Zealand

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