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Comparative Genomic Hybridization for the Analysis of Leukemias and Lymphomas

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Hematologic Malignancies

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 55))

Abstract

Cytogenetic methods have become increasingly important tools for both research in hematological malignancies and for the diagnostic workup of leukemias and lymphomas. The knowledge about specific chromosomal aberrations has been an essential prerequisite for the identification of pathogenetically relevant genes. Important examples are molecular genetic analyses of the breakpoint regions in chromosomal translocations, which resulted in the detection of protooncogenes such as ABL in chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) [t(9,22)(q34;q11)], or MYC in Burkitt’s lymphoma [t(8;14)(q24;q32); for a review see refs. 1 and 2].

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Author information

Authors and Affiliations

  1. Medizinische Klinik und Poliklinik V, Heidelberg, Germany

    Michael Baudis

  2. Abt. Innere Medizin III, Medizinische Klinik und Poliklinik, Ulm, Germany

    Martin Bentz

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  1. Michael Baudis
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  2. Martin Bentz
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Editors and Affiliations

  1. VA Medical Center and the Medical College of Georgia, Augusta, GA

    Guy B. Faguet

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© 2001 Humana Press Inc.

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Baudis, M., Bentz, M. (2001). Comparative Genomic Hybridization for the Analysis of Leukemias and Lymphomas. In: Faguet, G.B. (eds) Hematologic Malignancies. Methods in Molecular Medicine™, vol 55. Humana Press. https://doi.org/10.1385/1-59259-074-8:43

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  • DOI: https://doi.org/10.1385/1-59259-074-8:43

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-543-0

  • Online ISBN: 978-1-59259-074-2

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