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Immunohistochemical Analysis of Adhesion Molecules in Airway Biopsies

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Asthma

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 44))

Abstract

Adhesion molecules are receptors found on the surface of leukocytes and endothelial cells, which bind to their ligands, either on other cells or on the extracellular matrix. The function of adhesion molecules is to allow leukocytes to interact with other hemopoetic cells or with foreign antigens (Ags) in the blood, to transiently adhere to the vascular endothelium, to migrate between endothelial cells and through the basement membrane into the surrounding tissue, and to adhere to the epithelium. There are three main groups of adhesion molecules: the integrins, immunoglobulin (Ig) supergene family, and the selectins: These are summarized in Table 1 (17).

Table 1 Summary of Adhesion Molecules

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© 2000 Humana Press Inc.

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J. Wilson, S., T. Holgate, S. (2000). Immunohistochemical Analysis of Adhesion Molecules in Airway Biopsies. In: Fan Chung, K., Adcock, I. (eds) Asthma. Methods in Molecular Medicine™, vol 44. Humana Press. https://doi.org/10.1385/1-59259-072-1:227

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  • DOI: https://doi.org/10.1385/1-59259-072-1:227

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-626-0

  • Online ISBN: 978-1-59259-072-8

  • eBook Packages: Springer Protocols

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