Abstract
Granulocyte-macrophage colony-stimulating factor (GM-CSF), a 23-kDa polypeptide, was originally identified as a hematopoietic growth factor, but has recently been found to be a multifunctional cytokine with many proinflammatory activities (1,2). GM-CSF can be produced by, and act upon, a broad range of cell types, including both immature and mature granulocyte and monocyte lineage cells, dendritic cells, and tissue structural cells. Abundant in vitro observations have suggested that GM-CSF is able to induce both differentiation and activation of these cells (1).
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Xing, Z., Stämpfli, M.R., Gauldie, J. (2000). Transient Transgenic Approaches for Investigating the Role of GM-CSF in Pulmonary Inflammation and Immune Diseases. In: Fan Chung, K., Adcock, I. (eds) Asthma. Methods in Molecular Medicine™, vol 44. Humana Press. https://doi.org/10.1385/1-59259-072-1:161
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DOI: https://doi.org/10.1385/1-59259-072-1:161
Publisher Name: Humana Press
Print ISBN: 978-0-89603-626-0
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