Abstract
Although cancer is fundamentally a genetic disease, in the majority of cancers the mutations occur somatically (i.e., only in the tissue from which the cancer is derived). However, for many types of cancer, for example, breast, ovarian, and colorectal cancer there are a small number of cases that arise because of an inherited germline mutation. Genetic linkage analysis of such families enables the likely location of the TSG to be determined and has proven very successful in cloning some important TSGs. However, the genes responsible for inherited predisposition to cancer represent only a fraction of the total number of genetic defects that underlie the disease process.
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References
Knudson, A. G. (1993) Anti-oncogenes and human cancer. Proc. Natl. Acad. Sci. USA 90, 10,914ā10,921.
Pan, L. X., Diss, T. C., Peng, H. Z., and Isaacson, P. G. (1994) Clonality analysis of defined B-cell populations in archival tissue sections using microdissection and the polymerase chain reaction. Histopathology 24, 323ā327.
Jiang, X., Hitchcock, A., Bryan, E. J., Watson, R. H., Englefield, P., Thomas, E. J., and Campbell, I. G. (1996) Microsatellite analysis of endometriosis reveals loss of heterozygosity at candidate ovarian TSGloci. Cancer Res. 56, 3534ā3539.
Watson, R. H., Roy, W. J., Jr., Davis, M., Hitchcock, A., and Campbell, I. G. (1997) Loss of het-erozygosity at the-inhibin locus on chromosome 2q is not a feature of human granulosa cell tumors. Gynecol. Oncol. 65, 387ā390.
Roy, W. J., Jr., Watson, R. H., Hitchcock, A., and Campbell, I. G. (1997) Frequent loss of heterozy-gosity on chromosomes 7 and 9 in benign epithelial ovarian tumors. Oncogene 15, 2031ā2035.
Larson, A. A., Kern, S., Curtiss, S., Gordon, R., Cavenee, W. K., and Hampton, G. M. (1997) High resolution analysis of chromosome 3p alterations in cervical carcinoma. Cancer Res. 57, 4082ā4090.
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Ā© 2000 Humana Press Inc.
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Campbell, I.G., Bryan, E.J. (2000). Mapping of Tumor Suppressor Genes in Ovarian Cancers. In: Bartlett, J.M.S. (eds) Ovarian Cancer. Methods in Molecular Medicineā¢, vol 39. Humana Press. https://doi.org/10.1385/1-59259-071-3:365
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DOI: https://doi.org/10.1385/1-59259-071-3:365
Publisher Name: Humana Press
Print ISBN: 978-0-89603-583-6
Online ISBN: 978-1-59259-071-1
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