Radioreceptor Measurement of ER/PR Giovanni Scambia, Gabriella Ferrandina, G. D’Agostino,
Evidence that steroid hormones can play an important role in gynecological malignancies has been provided since 1896, when Sir George Beatson reported remissions in two patients with breast cancer after bilateral oophorectomy. All steroid hormones act on their target cells by binding to cellular receptors. Thus, the presence of the appropriate receptor in a tissue can be taken as a good indication that that tissue is hormonesensitive. Following these observations, many studies in this century have demonstrated that the knowledge of the steroid-receptor status of gynecological tumors, especially breast and endometrial cancer, can offer important information about the differentiation, response to endocrine therapy, and prognosis of the disease.
KeywordsGlycerol EDTA Cortisol Glucocorticoid Progesterone
- 2.EORTC (1980) Breast Cancer Cooperative Group Revision of the standards for the assessment of hormone receptors in human breast cancer. Eur. J. Cancer 16, 1513–1515.Google Scholar
- 4.Scambia, G., Benedetti-Panici, P., Ferrandina, G., Distefano, M., Salerno, G., Romanini, M. E., et al. (1995) Epidermal growth factor, oestrogen and progesterone receptor expression in primary ovarian cancer: correlation with clinical outcome and response to chemotherapy. Br. J. Cancer 72, 361–366.CrossRefPubMedGoogle Scholar
- 6.Wittliff, J. L., Pasic, R., and Bland, K. I. (1991) Steroid and peptide hormone receptors identified in breast tissue, in The Breast (Bland and Copeland, eds.), pp. 900–936.Google Scholar