Ovarian Cancer pp 493-497 | Cite as

Radioreceptor Measurement of ER/PR Giovanni Scambia, Gabriella Ferrandina, G. D’Agostino,

  • A. De Dilectis
  • Salvatore Mancuso
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 39)


Evidence that steroid hormones can play an important role in gynecological malignancies has been provided since 1896, when Sir George Beatson reported remissions in two patients with breast cancer after bilateral oophorectomy. All steroid hormones act on their target cells by binding to cellular receptors. Thus, the presence of the appropriate receptor in a tissue can be taken as a good indication that that tissue is hormonesensitive. Following these observations, many studies in this century have demonstrated that the knowledge of the steroid-receptor status of gynecological tumors, especially breast and endometrial cancer, can offer important information about the differentiation, response to endocrine therapy, and prognosis of the disease.


Endometrial Cancer Saturation Curve Bilateral Oophorectomy Gynecological Tumor Free Receptor 
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Copyright information

© Humana Press Inc. 2000

Authors and Affiliations

  • A. De Dilectis
    • 1
  • Salvatore Mancuso
    • 1
  1. 1.Department of Obstetrics and Gynecology, Laboratory of Antienoplastic Pharmacology ZenecaCatholic University of the Sacred HeartRomeItaly

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