Abstract
The popularity of the dietary restriction (DR) paradigm (often used interchangeably with calorie restriction) among gerontologists is primarily based on the research finding of the last two decades. Originally discovered by McCay’s group in the 1930s, this paradigm showed that animals placed on the DR regimen, meaning reduced nutrition without malnutrition, had robust life extensions (1). This scientific breakthrough showed that nutritional status can bring about distinctive metabolic adjustments.
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© 2000 Humana Press Inc., Totowa, NJ
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Yu, B.P. (2000). Dietary Restriction and Life-Span Extension. In: Barnett, Y.A., Barnett, C.R. (eds) Aging Methods and Protocols. Methods in Molecular Medicine, vol 38. Humana Press. https://doi.org/10.1385/1-59259-070-5:353
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DOI: https://doi.org/10.1385/1-59259-070-5:353
Publisher Name: Humana Press
Print ISBN: 978-0-89603-582-9
Online ISBN: 978-1-59259-070-4
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