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Epithelial-Mesenchymal Interactions

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Developmental Biology Protocols

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 137))

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Abstract

Cell-cell and tissue-tissue interactions initiate and regulate genomic expression in the initiation and maintenance of cell differentiation and tissue morphogenesis for virtually every vertebrate organ system. They operate as the major signaling system between microenvironment, extracellular milieu, cells, and tissues. Signaling can be direct, requiring establishment of intimate cell-to-cell contact between signaling and responding cells, or indirect, involving either release and recognition of signal molecules, or an interaction between responding cells and extracellular matrices of signaling cells.

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References

  1. Chandebois, R. and Faber, J. (1983) Automation in Animal Development: A New Theory Derived from the Concept of Cell Sociology. S. Karger AG, Basel.

    Google Scholar 

  2. Nieuwkoop, P. D., Johnen, A. G., and Albers, B. (1985) The Epigenetic Nature of Early Chordate Development. Cambridge University Press, Cambridge

    Google Scholar 

  3. Hall, B. K. (1983) Epigenetic control in development and evolution, in Development and Evolution (Goodwin, B. C., Holder, N. J., and Wylie, C. C., eds.), Cambridge University Press, Cambridge, pp. 353–379.

    Google Scholar 

  4. Goetinck, P. F. and Abbott, U. K. (1964) Studies on limb morphogenesis. 1. Experiments with the polydactylous mutant, Talpid2. J. Exp. Zool. 155, 161–170.

    Article  PubMed  CAS  Google Scholar 

  5. Sawyer, R. H., Abbott, U. K., and Trelford, J. D. (1972) Inductive interactions between human dermis and chick chorionic epithelium. Science 175, 527–529.

    Article  PubMed  CAS  Google Scholar 

  6. Bradamante, Z. and Hall, B. K. (1980) The role of epithelial collagen and proteoglycan in the initiation of osteogenesis by avian neural crest cells. Anat. Rec. 197, 305–315.

    Article  PubMed  CAS  Google Scholar 

  7. Sawyer, R. H. and Fallon, J. F., eds. (1983) Epithelial-Mesenchymal Interactions in Development. Praeger, New York.

    Google Scholar 

  8. Hall, B. K. (1980) Tissue interactions and the initiation of osteogenesis and chondrogenesis in the neural crest-derived mandibular skeleton of the embryonic mouse as seen in isolated, murine tissues and in recombination of murine and avian tissues. J. Embryol. Exp. Morphol. 58, 251–264.

    PubMed  CAS  Google Scholar 

  9. Cunha, G. R., Hayashi, N., and Wong, Y. C. (1992) Regulation of differentiation and growth of normal adult and neoplastic epithelia by inductive mesenchyme. Cancer Surveys 11, 73–90.

    Google Scholar 

  10. Hodges, G. M. and Rowlatt, C., eds. (1994) Developmental Biology and Cancer. CRC, Boca Raton, FL.

    Google Scholar 

  11. Dunlop, L.-L. L. and Hall, B. K. (1995) Relationships between cellular condensation, preosteoblast formation and epithelial-mesenchymal interactions in initiation of osteogenesis. Int. J. Dev. Biol. 39, 357–371.

    CAS  Google Scholar 

  12. Hall, B. K. and Van Exan, R. J. (1982) Induction of bone by epithelial cell products. J. Embryol. Exp. Morphol. 69, 37–46.

    PubMed  CAS  Google Scholar 

  13. Hall, B. K. (1983) Tissue interactions and chondrogenesis, in Cartilage, Volume 2, Development, Differentiation and Growth (Hall, B. K., ed.), Academic, New York, pp. 187–222.

    Google Scholar 

  14. Hall, B. K., Van Exan, R. J., and Brunt, S. L. (1983) Retention of epithelial basal lamina allows isolated mandibular mesenchyme to form bone. J. Craniofac. Genet. Dev. Biol. 3, 253–267.

    PubMed  CAS  Google Scholar 

  15. Hall, B. K. (1984) Matrices control the differentiation of cartilage and bone, in Matrices and Cell Differentiation (Kemp, R. B. and Hinchliffe, J. R., eds.), Alan R. Liss, New York, pp. 147–169.

    Google Scholar 

  16. Hall, B. K. (1978) Grafting of organs and tissues to the chorioallantoic membrane of the embryonic chick. Tissue Cult. Assoc. Man. 4, 881–884.

    Article  Google Scholar 

  17. Pinto, C. B. and Hall, B. K. (1991) Toward an understanding of the epithelial requirement for osteogenesis in scleral mesenchyme of the embryonic chick. J. Exp. Zool. 259, 92–108.

    Article  PubMed  CAS  Google Scholar 

  18. Sax’en, L. (1980) Mechanisms of morphogenetic tissue interactions: the message of transfilter experiments, in Differentiation and Neoplasia (McKinnell, R. G., Di Berardino, M. A., Blumenfeld, M., and Bergam, R. D., eds.), Springer-Verlag, Berlin, pp. 147–154.

    Google Scholar 

  19. Hall, B. K. (1983) Embryogenesis: cell-tissue interactions, in Skeletal Research: An Experimental Approach, vol. 2 (Kunin, A. S. and Simmons, D. J.,eds.), Academic, New York, pp. 53–87.

    Google Scholar 

  20. Van Exan, R. J. and Hall, B. K. (1984) Epithelial induction of osteogenesis in embryonic chick mandibular mesenchyme studied by transfilter tissue recombinations. J. Embryol. Exp. Morphol. 79, 225–242.

    PubMed  Google Scholar 

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© 2000 Humana Press Inc., Totowa, NJ

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Hall, B.K. (2000). Epithelial-Mesenchymal Interactions. In: Tuan, R.S., Lo, C.W. (eds) Developmental Biology Protocols. Methods in Molecular Biology™, vol 137. Humana Press. https://doi.org/10.1385/1-59259-066-7:235

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  • DOI: https://doi.org/10.1385/1-59259-066-7:235

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-854-7

  • Online ISBN: 978-1-59259-066-7

  • eBook Packages: Springer Protocols

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