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Assessment of Laterality Defects in Rodent Embryos

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Developmental Biology Protocols: Volume II

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 136))

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Abstract

How the left-right body axis is established during development and how abnormal sidedness of asymmetric body structures i.e., laterality defects or situs inversus (see Note 1), is induced during development have been questions of great interest in the history of science. A recent discovery of signaling molecules that are asymmetrically expressed before the establishment of morphological asymmetry in the chick embryo by Tabin and colleagues (1) has fueled the research of this area. Such investigations have been quickly expanded into mouse and rat embryos, the most commonly used mammalian experimental models (see Note 2).

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Author information

Authors and Affiliations

  1. Department of Anesthesia, Stanford University School of Medicine, Palo Alto, CA

    Masahiko Fujinaga

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  1. Masahiko Fujinaga
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Editor information

Editors and Affiliations

  1. Thomas Jefferson University, Philadelphia, PA

    Rocky S. Tuan

  2. University of Pennsylvania, Philadelphia, PA

    Cecilia W. Lo

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© 2000 Humana Press Inc.

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Fujinaga, M. (2000). Assessment of Laterality Defects in Rodent Embryos. In: Tuan, R.S., Lo, C.W. (eds) Developmental Biology Protocols: Volume II. Methods in Molecular Biology™, vol 136. Humana Press. https://doi.org/10.1385/1-59259-065-9:227

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  • DOI: https://doi.org/10.1385/1-59259-065-9:227

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-853-0

  • Online ISBN: 978-1-59259-065-0

  • eBook Packages: Springer Protocols

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