Abstract
Class II major histocompatibility complex (MHC-II) antigens (Ags) are integral membrane glycoproteins that have the unique capacity to bind prepro-cessed peptides, and present them to the immune system. These peptides are derived through a complex series of intracellular processing events that diverge among the plentitude of Ags presented in the context of MHC-II. The trimeric complex, consisting of peptide and class II α- and β-chains, is recognized by epitope specific CD4+T-cells. This fine specificity exhibited by the T-cell receptor is fundamental to the induction of tolerance and pathogen clearance. Therefore, delineating the mechanisms by which certain epitopes are generated and presented to CD4+T-cells may be useful in the development of immu-notherapies for solid tumors and autoimmune diseases, and more efficacious vaccines.
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Lich, J.D., Blum, J.S. (2000). Functional Analysis of Antigen Processing and Major Histocompatibility Complex Class II-Restricted Presentation. In: Solheim, J.C. (eds) Antigen Processing and Presentation Protocols. Methods in Molecular Biology, vol 156. Humana Press. https://doi.org/10.1385/1-59259-062-4:49
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DOI: https://doi.org/10.1385/1-59259-062-4:49
Publisher Name: Humana Press
Print ISBN: 978-0-89603-745-8
Online ISBN: 978-1-59259-062-9
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