Abstract
Since the discovery of cross priming by Bevan (1) nearly thirty years ago, a large amount of work has focused on defining the mechanisms that account for this in vivo phenomenon. Following the discovery that the majority of major histocompatibility complex (MHC-I)-bound peptides are derived from endogenous (intracellular) sources (2,3), a paradigm was established that exogenous (extracellular) antigens (Ags) are presented on MHC-I molecules and endogenous Ags are presented on MHC-II. In more recent years, accumulating evidence using a number of model systems, including presentation of bacterial (4,5), particulate (6) and soluble (7,8) Ag, has challenged that paradigm.
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Norbury, C.C. (2000). Tracing the Route Taken by Peptides and Major Histocompatibility Complex Class I Molecules in Presentation of Exogenous Antigens. In: Solheim, J.C. (eds) Antigen Processing and Presentation Protocols. Methods in Molecular Biology, vol 156. Humana Press. https://doi.org/10.1385/1-59259-062-4:33
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DOI: https://doi.org/10.1385/1-59259-062-4:33
Publisher Name: Humana Press
Print ISBN: 978-0-89603-745-8
Online ISBN: 978-1-59259-062-9
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