Abstract
Major histocompatibility complex class I (MHC-I) molecules alert cytotoxic T-lymphocytes to the presence of intracellular pathogens and tumors by presenting short peptides derived from pathogen- or tumor-specific proteins. To present a peptide, an MHC-I heavy chain (HC) binds the peptide and a small accessory protein called β2-microglobulin (β2m) in the endoplasmic reticulum (ER), and then migrates to the cell surface. The outer domains of the MHC-I HC and the antigenic peptide are then available to bind to T cell receptors.
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Turnquist, H.R., Solheim, J.C. (2000). Analysis of Major Histocompatibility Complex Class I Interactions with Endoplasmic Reticulum Proteins. In: Solheim, J.C. (eds) Antigen Processing and Presentation Protocols. Methods in Molecular Biology, vol 156. Humana Press. https://doi.org/10.1385/1-59259-062-4:165
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DOI: https://doi.org/10.1385/1-59259-062-4:165
Publisher Name: Humana Press
Print ISBN: 978-0-89603-745-8
Online ISBN: 978-1-59259-062-9
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