Abstract
Two isoforms of the serine/threonine kinase glycogen synthase kinase-3 (GSK-3) occur in mammalian cells, GSK-3α (53 kDa) and GSK-3β (47 kDa), which are 85% identical over the entire protein and 95% identical within the catalytic domain (1). GSK-3 is ubiquitously expressed in mammalian tissues and GSK-3 homologs have been identified in every eukaryotic species tested to date (2), strongly suggesting that it plays a central role in cellular regulation.
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Cross, D. (2000). Assays for Glycogen Synthase Kinase-3(GSK-3). In: Reith, A.D. (eds) Protein Kinase Protocols. Methods in Molecular Biology™, vol 124. Humana Press. https://doi.org/10.1385/1-59259-059-4:147
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DOI: https://doi.org/10.1385/1-59259-059-4:147
Publisher Name: Humana Press
Print ISBN: 978-0-89603-700-7
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