Locomotion of leukocytes is a complex event requiring coordinated activity of cytoskeletal, membrane, and adhesion systems (1). Prior to the migration of cells into the inflamed tissue, they have to pass the endothelium. This process involves several types of adhesion molecule interactions between eosinophils and endothelial cells. Selectins mediate two steps, initial tethering to the vessel wall and their subsequent rolling. Integrins then bind to endothelial receptors, increasing adhesion which results in the arrest of the rolling leukocytes, which can then cross the endothelial layer of the blood vessel and enter the tissue using integrins for traction (2, 3, 4, 5).
KeywordsActin Filament Adhesion System Rolling Leukocyte Subsequent Rolling Poisonous Mushroom
- 3.Nakayama H., Sano H., Nishimura T., Yoshidi S., and Iwamoto I. (1994) Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J. Exp. Med. 179, 1145–1154.CrossRefGoogle Scholar
- 9.Lawson M. A. and Maxfield F. R. (1995) Ca2+-and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils. Nature 37, 775-79.Google Scholar
- 14.Bengtsson T., Zalavary S., Stendahl O., and Grenegard M. (1996) Release of oxygen metabolites from chemoattractant-stimulated neutrophils is inhibited by resting platelets: Role of extracellular adenosine and actin polymerization. Blood 10, 4411–4423.Google Scholar