Abstract
An inherent consequence of calpain activation in situ is activation of the ubiquitous signal transduction kinase, protein kinase C (PKC). Whether or not one is directly interested in the effects of PKC, it may be important during experimental design and interpretation to consider that certain PKC-mediated events can essentially compete with calpain-mediated proteolysis. This chapter provides some general approaches that we have developed in our ongoing studies for modulating calpain-mediated PKC activation.
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Shea, T.B. (2000). Modulation of Calpain-Mediated Protein Kinase C Activation Within Intact Cells. In: Elce, J.S. (eds) Calpain Methods and Protocols. Methods in Molecular Biology™, vol 144. Humana Press. https://doi.org/10.1385/1-59259-050-0:309
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DOI: https://doi.org/10.1385/1-59259-050-0:309
Publisher Name: Humana Press
Print ISBN: 978-0-89603-632-1
Online ISBN: 978-1-59259-050-6
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