Abstract
Erythrocyte spectrin and nonerythroid spectrin (fodrin, calspectin) are major constituents of the membrane cytoskeleton, forming a two-dimensional meshwork beneath the outer cell membrane (1,2). The three-dimensional organization of the membrane cytoskeleton has been extensively studied in the erythrocyte, providing a model shown in (Fig.1) (1). Spectrin and fodrin are rod-shaped proteins and consist of α and β subunits (several isoforms exist) (1).
Schematic representation of the organization of spectrin cytoskeleton of erythrocyte.
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Yoshida, Ki. (2000). Myocardial Ischemia-Reperfusion Injury and Proteolysis of Fodrin, Ankyrin, and Calpastatin. In: Elce, J.S. (eds) Calpain Methods and Protocols. Methods in Molecular Biology™, vol 144. Humana Press. https://doi.org/10.1385/1-59259-050-0:267
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DOI: https://doi.org/10.1385/1-59259-050-0:267
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