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[3H]-GABA Binding to GABAA and GABAB Sites on Rat Brain Crude Synaptic Membranes

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Book cover Receptor Binding Techniques

Part of the book series: Methods in Molecular Biology ((MIMB,volume 106))

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Abstract

GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the central nervous system and acts on three pharmacologically distinct receptors: GABAA, GABAB, and GABAC. GABAA receptors are pharmacologically defined on the basis of antagonism by bicuculline and insensitivity to the GABA-analog baclofen, whereas GABAB receptors are stimulated by baclofen and are insensitive to bicuculline; GABAC receptors are insensitive to both (1).

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Author information

Authors and Affiliations

  1. Department of Medicine, University of Birmingham, Edgbaston, Birmingham, UK

    Rachel Bruton

  2. Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, Birmingham, UK

    Michelle Qume

Authors
  1. Rachel Bruton
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  2. Michelle Qume
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Editor information

Editors and Affiliations

  1. The Medical School, University of Birmingham, Birmingham, UK

    Mary Keen

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© 1999 Humana Press Inc., Totowa, NJ

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Bruton, R., Qume, M. (1999). [3H]-GABA Binding to GABAA and GABAB Sites on Rat Brain Crude Synaptic Membranes. In: Keen, M. (eds) Receptor Binding Techniques. Methods in Molecular Biology, vol 106. Springer, Totowa, NJ. https://doi.org/10.1385/0-89603-530-1:27

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  • DOI: https://doi.org/10.1385/0-89603-530-1:27

  • Publisher Name: Springer, Totowa, NJ

  • Print ISBN: 978-0-89603-530-0

  • Online ISBN: 978-1-59259-579-2

  • eBook Packages: Springer Protocols

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