Abstract
Hepatitis C virus (HCV) is believed to replicate via a viral-encoded, RNA-dependent RNA polymerase. This replication strategy has limited fidelity Thus, HCV is genetically heterogenous. To date, six HCV genotypes and more than 80 viral subtypes have been identified. Further, even within individually infected patients, HCV exists as a highly heterogenous population of closely related genome called quasispecies (1–3). Viral quasispecies have been shown to have important pathobiological implications.
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References
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© 1998 Humana Press Inc., Totowa, NJ
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Gonález-Peralta, R.P. (1998). Detection of Hepatitis C Virus Quasispecies Heterogeneity by Single-Strand Conformational Polymorphism. In: Lau, J.YN. (eds) Hepatitis C Protocols. Methods in Molecular Medicine™, vol 19. Humana Press. https://doi.org/10.1385/0-89603-521-2:213
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DOI: https://doi.org/10.1385/0-89603-521-2:213
Publisher Name: Humana Press
Print ISBN: 978-0-89603-521-8
Online ISBN: 978-1-59259-260-9
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