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Detection of Hepatitis C Virus Quasispecies Heterogeneity by Single-Strand Conformational Polymorphism

  • Regino P. Gonález-Peralta
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 19)

Abstract

Hepatitis C virus (HCV) is believed to replicate via a viral-encoded, RNA-dependent RNA polymerase. This replication strategy has limited fidelity Thus, HCV is genetically heterogenous. To date, six HCV genotypes and more than 80 viral subtypes have been identified. Further, even within individually infected patients, HCV exists as a highly heterogenous population of closely related genome called quasispecies (1, 2, 3). Viral quasispecies have been shown to have important pathobiological implications.

Keywords

SSCP Analysis Viral Quasispecies Quasispecies Population Phast System Briefly Centrifuge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc., Totowa, NJ 1998

Authors and Affiliations

  • Regino P. Gonález-Peralta

There are no affiliations available

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