Abstract
The success of many tissue engineering applications depends on a scaffold with the suitable physical properties, one of which might be a macroporous structure that allows cellular ingrowth. Such a porous implant further raises the possibility of delivering chemotactic or growth factors to influence the course of cell proliferation and differentiation in situ. The scaffolds can also be preseeded with cells to accelerate tissue growth or repair. Even in the absence of these payloads, they still provide the benefit of introducing the minimal amount of foreign material into the tissue. Furthermore, by making the porous scaffold, or foam, from biodegradable polymers, the regenerated tissue would be rid of any synthetic component, leading to a more functional biological equivalent, and eliminating concerns of long-term tissue compatibility.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ducheyne, P. (1985) Success of prosthetic devices fixed by ingrowth or surface interaction. Acta Orthop. Belg. 51, 144ā161.
Schliephake, H., Neukam, F. W., and Klosa, D. (1991) Influence of pore dimensions on bone ingrowth into porous hydroxyapatite blocks used as bone graft substitutes. A histometric study. Int. J. Oral. Maxillofac. Surg. 20, 53ā58.
Eggli, P. S., Muller, W., and Schenk, R. K. (1988) Porous hydroxyapatite and tricalcium phosphate cylinders with two different pore size ranges implanted in the cancellous bone of rabbits. A comparative histomorphometric and histologic study of bony ingrowth and implant substitution. Clin. Orthop. Rel. Res. 232, 127ā138.
Collier, J. P., Mayor, M. B., Chae, J. C., Surprenant, V. A., Surprenant, H. P., and Dauphinais, L. A. (1988) Macroscopic and microscopic evidence of prosthetic fixation with porous-coated materials. Clin. Orthop. 235, 173ā180.
Kadiyala, S., Lo, H., and Leong K. W. (1994) Biodegradable polymers as synthetic bone grafts, in Bone Formation and Repair (Brighton, C. T., Friedlander, G., Lane, J. M, eds.), AAOS, Boca Raton, FL.
Lo, H., Kadiyala, S., Guggio, S. E., and Leong, K. W. (1996) Poly(L-lactic acid) foams with cell seeding and controlled-release capacity. J. Biomed. Mater. Res. 30, 475ā484.
Lo, H., Ponticiello, M. S., and Leong, K. W. (1996) Fabrication of controlled release biodegradable foams by phase separation. Tissue Eng. 1, 15ā28.
Tanaka, H. and Nishi, T. (1987) Direct determination of the probability determination of concentration in polymer mixtures undergoing phase separation. Phys. Rev. Lett. 59, 692ā695.
Siggia, E. D. (1979) Late stages of spinodal decomposition in binary mixtures. Phys. Rev. A20, 595ā605.
Aubert, J. H. (1988) Interfacial tension of demixed polymer solutions. Polymer. 29, 118ā122
Kadiyala, S., Lo, H., Ponticiello, M. S., Reddi, A. H., and Leong, K. W. (1996) Bone induction achieved by controlled release of BMP from PLA/Hydroxyapatite foams, in Transactions of the Fifth World Biomaterials Congress, Toronto, p. 289.
Zaks, A. and Klibanov, A. M. (1984) Enzymatic catalysis in organic media at 100 degrees C. Science 1249ā1251.
Zaks, A. and Klibanov, A. M. (1988) Enzymatic catalysis in nonaqueous solvents. J. Biol. Chem. 263, 3194ā3201.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
Ā© 1999 Humana Press Inc., Totowa, NJ
About this protocol
Cite this protocol
Kadiyala, S., Lo, H., Leong, K.W. (1999). Formation of Highly Porous Polymeric Foams with Controlled Release Capability. In: Morgan, J.R., Yarmush, M.L. (eds) Tissue Engineering Methods and Protocols. Methods in Molecular Medicineā¢, vol 18. Humana Press. https://doi.org/10.1385/0-89603-516-6:57
Download citation
DOI: https://doi.org/10.1385/0-89603-516-6:57
Publisher Name: Humana Press
Print ISBN: 978-0-89603-516-4
Online ISBN: 978-1-59259-602-7
eBook Packages: Springer Protocols