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Preparation and Use of Porous Poly(α-Hydroxyester) Scaffolds for Bone Tissue Engineering

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Tissue Engineering Methods and Protocols

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 18))

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Abstract

Skeletal defects resulting from tumor resection, congenital abnormalities, or trauma often require surgical intervention to restore function. Current options for bone replacement include autografts, allografts, metals, ceramics, and polymeric bone cements. However, all of these materials have drawbacks, and their selection usually requires some degree of compromise. Autografts represent the ideal repair material, but are limited by availability and donor site morbidity. Allografts may be potential transmitters of disease, and also solicit immune response if not sufficiently pretreated. Ceramics suffer from slow integration and remodeling, and wear-debris from nondegradable polymeric implants may evoke chronic inflammation. Finally, metallic implants may cause atrophy of surrounding tissue through stress shielding, requiring corrective procedures.

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Author information

Authors and Affiliations

  1. Cox Laboratory for Biomedical Engineering, Department of Chemical Engineering, Rice University, Houston, TX

    Anna C. Jen, Susan J. Peter & Antonios G. Mikos

Authors
  1. Anna C. Jen
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  2. Susan J. Peter
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  3. Antonios G. Mikos
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Editor information

Editors and Affiliations

  1. Center for Engineering in Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    Jeffrey R. Morgan PhD  & Martin L. Yarmush MD  & 

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© 1999 Humana Press Inc., Totowa, NJ

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Jen, A.C., Peter, S.J., Mikos, A.G. (1999). Preparation and Use of Porous Poly(α-Hydroxyester) Scaffolds for Bone Tissue Engineering. In: Morgan, J.R., Yarmush, M.L. (eds) Tissue Engineering Methods and Protocols. Methods in Molecular Medicine™, vol 18. Humana Press. https://doi.org/10.1385/0-89603-516-6:133

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  • DOI: https://doi.org/10.1385/0-89603-516-6:133

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-516-4

  • Online ISBN: 978-1-59259-602-7

  • eBook Packages: Springer Protocols

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